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Titolo:
Interaction of metallopyrazoliumylporphyrins with calf thymus DNA
Autore:
Tjahjono, DH; Mima, S; Akutsu, T; Yoshioka, N; Inoue, H;
Indirizzi:
Keio Univ, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan Keio Univ Yokohama Kanagawa Japan 2238522 kohama, Kanagawa 2238522, Japan
Titolo Testata:
JOURNAL OF INORGANIC BIOCHEMISTRY
fascicolo: 2-3, volume: 85, anno: 2001,
pagine: 219 - 228
SICI:
0162-0134(200106)85:2-3<219:IOMWCT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEIC-ACIDS; CATIONIC PORPHYRINS; B-DNA; SUPRAMOLECULAR CHEMISTRY; BINDING PROPERTIES; STRAND SCISSION; INDUCED CD; LIGAND; DERIVATIVES; PHOTOCLEAVAGE;
Keywords:
cationic pyrazoliumylporphyrin; metalloporphyrins; calf thymus DNA; porphyrin-DNA interaction; thermodynamic parameters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Tjahjono, DH Keio Univ, Dept Appl Chem, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan Keio Univ 3-14-1 Hiyoshi Yokohama Kanagawa Japan2238522 apan
Citazione:
D.H. Tjahjono et al., "Interaction of metallopyrazoliumylporphyrins with calf thymus DNA", J INORG BIO, 85(2-3), 2001, pp. 219-228

Abstract

The interaction of transition metal complexes of cationic porphyrins bearing five membered rings, Meso-tetrakis(1,2-dimethylpyrazolium-4-yL)porphyrin(MPzP, M=Mn-III, Ni-II, CUII or Zn-II), with calf thymus DNA (ctDNA) has been studied. Metalloporphyrins NiPzP and CuPzP are intercalated into the 5 ' GC3 ' step of ctDNA. MnPzP is bound edge-on at the 5 ' TA3 ' step of the minor groove of ctDNA, while ZnPzP is bound face-on at the 5 ' TA3 ' step of the major groove of ctDNA. The binding constants of the metalloporphyrinsto ctDNA range from 1.05X10(5) to 2.66X10(6) M-1 and are comparable to those of other reported cationic porphyrins. The binding process of the metallopyrazoliumylporphyrins to ctDNA is endothermic and entropically driven. The:je results have revealed that the kind of central metal ions of metalloporphyrins influences the binding characteristics of the porphyrin to DNA. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/11/20 alle ore 01:21:42