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Titolo:
Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: Frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate
Autore:
Manfredi, R; Chiodo, F;
Indirizzi:
Univ Bologna, S Orsola M Malpighi Hosp, Div Infect Dis, Dept Clin & Expt Med, I-40138 Bologna, Italy Univ Bologna Bologna Italy I-40138 in & Expt Med, I-40138 Bologna, Italy
Titolo Testata:
JOURNAL OF INFECTION
fascicolo: 3, volume: 42, anno: 2001,
pagine: 181 - 188
SICI:
0163-4453(200104)42:3<181:DOLMIP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEASE INHIBITOR THERAPY; CORONARY-ARTERY DISEASE; RITONAVIR THERAPY; INFECTED PATIENTS; BUFFALO HUMP; LIPODYSTROPHY; HYPERTRIGLYCERIDEMIA; ABNORMALITIES; DYSLIPIDEMIA; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Manfredi, R Univ Bologna, S Orsola M Malpighi Hosp, Div Infect Dis, Dept Clin & Expt Med, Via Massarenti 11, I-40138 Bologna, Italy Univ Bologna Via Massarenti 11 Bologna Italy I-40138 a, Italy
Citazione:
R. Manfredi e F. Chiodo, "Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: Frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate", J INFECTION, 42(3), 2001, pp. 181-188

Abstract

Objectives: To assess the correlation between antiretroviral treatment anddyslipidaemia in HIV-infected patients, and the role of bezafibrate as a lipid-lowering agent. Methods: We retrospectively compared serum lipid levels of five groups of 40 patients, each of them treated with either saquinavir hard gel, indinavir, or ritonavir (associated with two nucleoside analogues), or dual nucleoside reverse transcriptase inhibitors (NRTI) with or without a non-nucleoside reverse transcriptase inhibitor (NNRTI), or not treated with antiretrovirals, randomly selected from nearly 1000 HIV-infected patients followed-up for greater than or equal to 12 months, while on the relevant therapy. Hypertriglyceridaemia was defined by triglyceride levels greater than or equal to 172 mg/dl, and hypercholesterolaemia by cholesterol levels greater than or equal to 200 mg/dl, All patients with triglyceridaemia >300 mg/dl and cholesterolaemia >220 mg/dl for at least 6 months, and unresponsive to a greater than or equal to3-month diet, started bezafibrate (400 mg/day), and wereprospectively followed-up at a greater than or equal to3-month interval, evaluating both efficacy and tolerability of the hypolipidaemic treatment, provided that they did not change their protease inhibitor treatment for reasons other than metabolic abnormalities. Results: Hypertrygliceridaemia occurred in 75 patients out of 200 (37.5%),but was significantly more frequent and severe with ritonavir vs. indinavir (P < 0.001), and in subjects given indinavir vs. all remaining patients (either treated or not) (P < 0.001), while isolated saquinavir use was associated with higher tri glyceride levels than NRTI-NNRTI treatment alone, or no antiretroviral therapy (P < 0.03). Hypercholesterolaemia was found in 27subjects (13.5%), and a significantly higher frequency and severity was shown in patients treated with indinavir and ritonavir vs, saquinavir, NRTI-NNRTI, and no anti-HIV therapy (P < 0.05 to P < 0.001), No appreciable difference was found between patients undergoing NRTI-NNRTI and untreated controls, for all evaluated variables. Bezafibrate was administered once daily for 6-18 months to 49 patients with elevated and diet-resistant hyperlipidaemia due to ritonavir or indinavir (27 and 22 subjects, respectively), and reduced triglyceride and cholesterol levels by 35% and 25%, respectively over6 months, without differences between the underlying protease inhibitor regimen. Thirty-three patients (67.3%) reached a normal triglyceridaemia after 6-9 months, and normal cholesterol levels were obtained in all subjects. Bezafibrate proved safe and well tolerated. Conclusions: Careful monitoring of the serum lipid profile is needed during antiretroviral therapy, including protease inhibitors, to identify the need for a diet and/or an hypolipidaemic treatment, and to prevent clinical sequelae related to long-term dyslipidaemia. Specific guidelines for the management of disorders of lipid metabolism in HIV-infected patients are needed. (C) 2001 The British Infection Society.

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Documento generato il 18/01/20 alle ore 07:27:55