Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Fibroblast Na+-Li+ countertransport rate is elevated in essential hypertension
Autore:
Zerbini, G; Podesta, F; Meregalli, G; Deferrari, G; Pontremoli, R;
Indirizzi:
Univ Milan, Renal Pathophysiol Lab, Div Med, San Raffaele Sci Inst, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 n Raffaele Sci Inst, I-20122 Milan, Italy Univ Genoa, Dept Internal Med, I-16126 Genoa, Italy Univ Genoa Genoa Italy I-16126 , Dept Internal Med, I-16126 Genoa, Italy
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 7, volume: 19, anno: 2001,
pagine: 1263 - 1269
SICI:
0263-6352(200107)19:7<1263:FNCRIE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM-LITHIUM COUNTERTRANSPORT; HUMAN RED-CELLS; PROTON EXCHANGE; BLOOD-CELLS; HUMAN-ERYTHROCYTES; ANTIPORT ACTIVITY; INTRACELLULAR PH; H+ EXCHANGE; TRANSPORT; FLUXES;
Keywords:
essential hypertension; Na plus -Li plus countertransport; human skin fibroblast; Na plus -H plus exchange;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Zerbini, G San Raffaele Sci Inst, Div Med 1, Via Olgettina 60, I-20132 Milan, Italy San Raffaele Sci Inst Via Olgettina 60 Milan Italy I-20132 aly
Citazione:
G. Zerbini et al., "Fibroblast Na+-Li+ countertransport rate is elevated in essential hypertension", J HYPERTENS, 19(7), 2001, pp. 1263-1269

Abstract

Objectives Elevated erythrocyte Na+-Li+ countertransport (SLC) rates are commonly found in essential hypertension. We have recently shown that human skin fibroblasts functionally express a phloretin-sensitive Na+-H+ exchange(NHE) which may also be similar to erythrocyte SLC because of amiloride-insensitivity. Design and methods We investigated whether elevations in fibroblast SLC parallel the known elevations in erythrocyte SLC and in cell NHE that characterize essential hypertension,Results Higher fibroblast SLC rates were found among hypertensive patients(n = 23, median 48.8 nmol Li+/mg(protein) per min) than in 19 normotensiveindividuals of similar age and sex (median 14.8 nmol Li+/mg(protein) per min, P = 0.0002). As expected, erythrocyte SLC was elevated in patients withhypertension (median 411 versus 329 mu mol/l(cell) per h, P = 0.0273), butwas not quantitatively related to fibroblast SLC, Finally, fibroblast NHE exchange activity was higher in essential hypertension (median V-max 14.2 versus 7.6 mmol H+/I-cell per min, P = 0.002), but was unrelated to fibroblast SLC. Conclusions These findings extend to human skin fibroblasts the notion of abnormal Li+ transport in essential hypertension, and appear to be in accordance with the hypothesis that fibroblast SLC may be independent of NHE, However, molecular studies will be required to understand whether distinct exchangers and/or regulation mechanisms underlie these dysregulations. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:01:21