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Titolo:
Immature hepatic tumor of bimodal differentiation in a young adult patient: a novel lesion expressing beta-catenin and mimicking a distinct phase of hepatogenesis
Autore:
Gornicka, B; Ziarkiewicz-Wroblewska, B; Michalowicz, B; Pawlak, J; Wroblewski, T; Krawczyk, M; Wasiutynski, A; Kappeler, A; Zimmermann, A;
Indirizzi:
Med Univ Warsaw, Dept Pathomorphol, Warsaw, Poland Med Univ Warsaw Warsaw Poland Warsaw, Dept Pathomorphol, Warsaw, Poland Med Univ Warsaw, Dept Gen & Liver Surg, Warsaw, Poland Med Univ Warsaw Warsaw Poland aw, Dept Gen & Liver Surg, Warsaw, Poland Univ Bern, Inst Pathol, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 nst Pathol, CH-3010 Bern, Switzerland
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 6, volume: 34, anno: 2001,
pagine: 955 - 961
SICI:
0168-8278(200106)34:6<955:IHTOBD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEM-CELL FACTOR; EPITHELIAL MEMBRANE ANTIGEN; SARCOMATOID HEPATOCELLULAR-CARCINOMA; UNDIFFERENTIATED EMBRYONAL SARCOMA; PRIMARY LIVER CARCINOMAS; C-KIT; ALPHA-FETOPROTEIN; PROGENITOR-CELL; CARCINOEMBRYONIC ANTIGEN; PARAFFIN SECTIONS;
Keywords:
liver cell tumor; beta-catenin; hepatogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Gornicka, B Med Univ Warsaw, Dept Pathomorphol, Warsaw, Poland Med Univ Warsaw Warsaw Poland Pathomorphol, Warsaw, Poland
Citazione:
B. Gornicka et al., "Immature hepatic tumor of bimodal differentiation in a young adult patient: a novel lesion expressing beta-catenin and mimicking a distinct phase of hepatogenesis", J HEPATOL, 34(6), 2001, pp. 955-961

Abstract

Patient and methods: A large right-sided liver tumor was incidentally discovered and totally resected in a 21-year-old female patient without chronicliver disease. Histopathologic examination revealed that this malignant tumor does not fit any of the known types of primary liver tumors reported thus far. Results: The lesion chiefly consisted of numerous solid nests composed of immature epithelial cells disclosing a marker profile typical for hepatocytes and strongly expressing beta -catenin, These nests were tightly associated with abnormal duct-like profiles exhibiting features of bile duct cells. Conclusions: The finding of numerous neoplastic hepatobiliary units ('liverlets') suggests that this tumor may mimic a distinct developmental phase of hepatogenesis close to ductal plate formation. (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science B.V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 18:32:44