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Titolo:
Endothelin-1 plays a major role in portal hypertension of biliary cirrhotic rats through endothelin receptor subtype B together with subtype A in vivo
Autore:
Kojima, H; Sakurai, S; Kuriyama, S; Yoshiji, H; Imazu, H; Uemura, M; Nakatani, Y; Yamao, J; Fukui, H;
Indirizzi:
Nara Med Univ, Dept Internal Med 3, Kashihara, Nara 634, Japan Nara Med Univ Kashihara Nara Japan 634 Med 3, Kashihara, Nara 634, Japan
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 6, volume: 34, anno: 2001,
pagine: 805 - 811
SICI:
0168-8278(200106)34:6<805:EPAMRI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
STELLATE CELLS; IN-VIVO; PHARMACOLOGICAL PROFILE; ETB RECEPTORS; LIVER-INJURY; ANTAGONIST; HEMODYNAMICS; RESISTANCE; PRESSURE; POTENT;
Keywords:
endothelin; endothelin receptor; portal hypertension; liver cirrhosis; bile duct ligation; RNA expression; hemodynamic study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, H Nara Med Univ, Dept Internal Med 3, 840 Shijo Cho, Kashihara, Nara 634, Japan Nara Med Univ 840 Shijo Cho Kashihara Nara Japan 634 634, Japan
Citazione:
H. Kojima et al., "Endothelin-1 plays a major role in portal hypertension of biliary cirrhotic rats through endothelin receptor subtype B together with subtype A in vivo", J HEPATOL, 34(6), 2001, pp. 805-811

Abstract

Background/Aims: Endothelin-1 has been suggested to play a key role in cirrhotic portal hypertension, but a role of its receptors in vivo is not fully elucidated. Methods: Biliary cirrhosis was induced by bile duct ligation. Expressions of endothelin-l and its receptors were evaluated by radioimmunoassay and/orreverse-transcription polymerase chain reaction, Hemodynamics were studiedusing endothelin receptor agonist or antagonist. Results: Portal pressure and hepatic endothelin-1 concentrations progressively increased in parallel after bile duct ligation, Gene expression of hepatic prepro-endothelin-1 and endothelin B receptor enhanced after bile ductligation, while that of endothelin A receptor was unchanged. Intraportal administration of endothelin-1 or endothelin B receptor agonist sarafotoxin 6c (0.5 nmol/kg, respectively) progressively raised portal pressure in bothsham and cirrhotic rats. Portal hypertensive effect of sarafotoxin 6c was more intense in cirrhotic rats than sham animals, Neither endothelin A receptor antagonist FR139317 (1 mg/kg) nor endothelin B receptor antagonist BQ788 (1 mg/kg) alone ameliorated cirrhotic portal hypertension. Only the combined endothelin A and B blockade was associated with a decrease in portal pressure in cirrhotic rats. Conclusions: These results indicate that endothelin-1 plays a major role in cirrhotic portal hypertension through endothelin receptor subtype B together with subtype A in vivo. (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science B.V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:00:38