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Titolo:
Do some antidepressants work faster than others?
Autore:
Nierenberg, AA;
Indirizzi:
Massachusetts Gen Hosp, Dept Psychiat, Depress Clin & Res Program, Boston,MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 s Program, Boston,MA 02114 USA Massachusetts Gen Hosp, Dept Psychiat, Biopolar Program, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Program, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
, volume: 62, anno: 2001, supplemento:, 15
pagine: 22 - 25
SICI:
0160-6689(2001)62:<22:DSAWFT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND; MIRTAZAPINE; VENLAFAXINE; TOLERABILITY; MELANCHOLIA; PAROXETINE; FLUOXETINE; EFFICACY; ONSET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Nierenberg, AA Massachusetts Gen Hosp, Dept Psychiat, Depress Clin & Res Program, 15 Parkman St,ACC 812, Boston, MA 02114 USA Massachusetts Gen Hosp 15 Parkman St,ACC 812 Boston MA USA 02114
Citazione:
A.A. Nierenberg, "Do some antidepressants work faster than others?", J CLIN PSY, 62, 2001, pp. 22-25

Abstract

The clinical utility of antidepressant drugs is impaired by the delay in onset of their therapeutic action. It is becoming increasingly clear that differences exist between antidepressants with respect to this property, bothwithin and between pharmacologic classes. Post hoc analyses of comparisonsbetween selective serotonin reuptake inhibitors and dual-action antidepressants such as mirtazapine and venlafaxine indicate that the dual-action drugs may have a faster onset of action. At least in the case of mirtazapine, the earlier onset appears to be via a specific antidepressant effect and not an effect on sleep or other accessory symptoms. Studies that compare mirtazapine and venlafaxine are relatively rare and lack sufficient statisticalpower to determine a difference in the onset of action. Although these differences have been shown in clinical efficacy studies not specifically designed to detect differences in onset of action, a definitive demonstration of early onset of action awaits the results of appropriately designed and powered clinical studies currently planned or in progress.

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Documento generato il 22/09/20 alle ore 14:26:17