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Titolo:
Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport
Autore:
Ozawa, K; Kondo, T; Hori, O; Kitao, Y; Stern, DM; Eisenmenger, W; Ogawa, S; Ohshima, T;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Neuroanat, Fac Med, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan Japan Sci & Technol, CREST, Kawaguchi, Japan Japan Sci & Technol Kawaguchi Japan & Technol, CREST, Kawaguchi, Japan Kanazawa Univ, Fac Med, Dept Legal Med, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan Columbia Univ, Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York, NY USA Columbia Univ New York NY USA ysiol & Cellular Biophys, New York, NY USA Univ Munich, Dept Legal Med, Munich, Germany Univ Munich Munich GermanyUniv Munich, Dept Legal Med, Munich, Germany
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 1, volume: 108, anno: 2001,
pagine: 41 - 50
SICI:
0021-9738(200107)108:1<41:EOTOPO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; KAPPA-B-ALPHA; MONONUCLEAR PHAGOCYTES; MEDIATED INDUCTION; NITRIC-OXIDE; HYPOXIA; GENE; CELLS; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Ozawa, K Kanazawa Univ, Sch Med, Dept Neuroanat, Fac Med, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9208640 n
Citazione:
K. Ozawa et al., "Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport", J CLIN INV, 108(1), 2001, pp. 41-50

Abstract

Expression of angiogenic factors such as VEGF under conditions of hypoxia or other kinds of cell stress contributes to neovascularization during wound healing. The inducible endoplasmic reticulum chaperone oxygen-regulated protein 150 (ORP150) is expressed in human wounds along with VEGF. Colocalization of these two molecules was observed in macrophages in the neovasculature, suggesting a role of ORP150 in the promotion of angiogenesis. Local administration of ORP150 sense adenovirus to wounds of diabetic mice, a treatment that efficiently targeted this gene product to the macrophages of wound beds, increased VEGF antigen in wounds and accelerated repair and neovascularization. In cultured human macrophages, inhibition of ORP150 expressioncaused retention of VEGF antigen within the endoplasmic reticulum (ER), while overexpression of ORP150 promoted the secretion of VEGF into hypoxic culture supernatants, Taken together, these data suggest an important role for ORD150 in the setting of impaired wound repair and identify a key, inducible chaperone-like molecule in the ER. This novel facet of the angiogenic response may be amenable to therapeutic manipulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:25:41