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Titolo:
Neonatal ketosis is not rare: experience of neonatal screening using gas chromatography-mass spectrometry
Autore:
Inokuchi, T; Yoshida, I; Kaneko, A; Tashiro, K; Tashiro, S; Jogo, M; Aoki, K; Tanaka, M;
Indirizzi:
Kurume Univ, Sch Med, Res Inst Med Mass Spectrometry, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 , Kurume, Fukuoka 8300011, Japan Kurume Univ, Sch Med, Dept Pediat, Kurume, Fukuoka 830, Japan Kurume UnivKurume Fukuoka Japan 830 t Pediat, Kurume, Fukuoka 830, Japan Kurume Univ, Sch Med, Dept Med Educ, Kurume, Fukuoka 830, Japan Kurume Univ Kurume Fukuoka Japan 830 Med Educ, Kurume, Fukuoka 830, Japan Kurume Univ, Sch Med, Dept Pharmacol, Kurume, Fukuoka 830, Japan Kurume Univ Kurume Fukuoka Japan 830 harmacol, Kurume, Fukuoka 830, Japan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 758, anno: 2001,
pagine: 57 - 60
SICI:
1387-2273(20010705)758:1<57:NKINRE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLISM;
Keywords:
neonatal ketosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Inokuchi, T Kurume Univ, Sch Med, Res Inst Med Mass Spectrometry, 67 AsahiMachi, Kurume, Fukuoka 8300011, Japan Kurume Univ 67 Asahi Machi Kurume Fukuoka Japan 8300011 Japan
Citazione:
T. Inokuchi et al., "Neonatal ketosis is not rare: experience of neonatal screening using gas chromatography-mass spectrometry", J CHROMAT B, 758(1), 2001, pp. 57-60

Abstract

The causes and effects of transient neonatal ketosis, discovered during a pilot study of screening for abnormalities in neonatal metabolism using gaschromatography-mass spectrometry, were investigated. Of the 21 342 neonates that were screened, 47 had significant ketosis. The organic acid profile accompanying ketosis in the urine of neonates followed the pattern of ketotic dicarboxylic aciduria in approximately half of the cases. Ketosis was more often found in neonates nourished by breast feeding (33 out of 47). Overhalf of the neonates showing ketosis (28 out of 47) were asymptomatic. When normal neonates and neonates testing positive for ketosis were compared, no statistically significant correlations were found with regard to birth mass, gestational period, or gender. However, neonates with ketosis tended to have low mass gain rates in the 5 days from birth and a statistically significant difference was found in this regard in comparison to normal neonates (P <0.0001). From the above results, development of ketosis in neonates was found to be possible even in normal subjects. Most ketosis in neonates was also found to depend largely on nourishment after birth. Existence of an asymptomatic ketosis category was also suggested. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:37:09