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Titolo:
Determination of quaternary alkylammonium compounds by capillary zone electrophoresis and indirect UV detection as a real alternative to ion chromatography with suppressed conductivity detection
Autore:
Schoftner, R; Buchberger, W; Malissa, H;
Indirizzi:
Univ Linz, Dept Analyt Chem, A-4040 Linz, Austria Univ Linz Linz AustriaA-4040 nz, Dept Analyt Chem, A-4040 Linz, Austria Salzburg Univ, Dept Chem & Biochem, A-5020 Salzburg, Austria Salzburg Univ Salzburg Austria A-5020 Biochem, A-5020 Salzburg, Austria
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1-2, volume: 920, anno: 2001,
pagine: 333 - 344
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIRECT PHOTOMETRIC DETECTION; PERFORMANCE LIQUID-CHROMATOGRAPHY; ELECTROSPRAY MASS-SPECTROMETRY; AMMONIUM-COMPOUNDS; CATIONIC SURFACTANTS; CONDUCTOMETRIC DETECTION; PAIR CHROMATOGRAPHY; ANIONIC SURFACTANTS; GAS-CHROMATOGRAPHY; BIOGENIC-AMINES;
Keywords:
indirect detection; detection, LC; quaternary ammonium compounds;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Schoftner, R Univ Linz, Dept Analyt Chem, Altenbergerstr 69, A-4040 Linz, Austria Univ Linz Altenbergerstr 69 Linz Austria A-4040 inz, Austria
Citazione:
R. Schoftner et al., "Determination of quaternary alkylammonium compounds by capillary zone electrophoresis and indirect UV detection as a real alternative to ion chromatography with suppressed conductivity detection", J CHROMAT A, 920(1-2), 2001, pp. 333-344

Abstract

A capillary electrophoretic (CE) method for the determination of residual mid-chain alkyltrimethylammonium compounds in the pharmaceutical product Welchol (TM) tan alkylated, crosslinked polyallylamine) was developed, validated and compared with the existing ion chromatographic (IC) method with suppressed conductivity detection. Excellent reproducibilities of migration times (RSD <0.5% within a series of 55 sample injections) and relative peak areas (RSD <2%) make the method suitable for quality central as a real alternative to IC. Limits of quantification of 0.01% w/w of each impurity in theactive substance were achieved. Buffer systems for indirect UV detection based on creatinine as visualization reagent with different inorganic and organic acids (phosphoric, sulfuric, formic, acetic, oxalic and citric acid) and their effect on selectivity to ten quaternary ammonium compounds were studied. Selectivity changes were observed for the di- and trivalent analytes depending on the buffer applied. Also, the influence of acetonitrile, methanol, I, ct-dioxane and tetrahydrofuran on selectivity was investigated. In addition, CE-MS experiments were carried out in order to identify severalimpurities in the product. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 20/10/20 alle ore 04:27:08