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Titolo:
Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma: Results in eleven cases
Autore:
Longhi, A; Fabbri, N; Donati, D; Capanna, R; Briccoli, A; Biagini, R; Bernini, G; Ferrari, S; Versari, M; Bacci, G;
Indirizzi:
Ist Ortoped Rizzoli, Sez Chemioterapia, Dept Chemotherapy, I-40136 Bologna, Italy Ist Ortoped Rizzoli Bologna Italy I-40136 herapy, I-40136 Bologna, Italy Ist Ortoped Rizzoli, Ward Orthoped Surg 5, I-40136 Bologna, Italy Ist Ortoped Rizzoli Bologna Italy I-40136 Surg 5, I-40136 Bologna, Italy Ist Ortoped Rizzoli, Gen Surg Ward, I-40136 Bologna, Italy Ist Ortoped Rizzoli Bologna Italy I-40136 g Ward, I-40136 Bologna, Italy CTO Firenze, Dept Orthoped Clin, Florence, Italy CTO Firenze Florence Italy Firenze, Dept Orthoped Clin, Florence, Italy Childrens Hosp, Ist Meyer, Florence, Italy Childrens Hosp Florence Italy hildrens Hosp, Ist Meyer, Florence, Italy
Titolo Testata:
JOURNAL OF CHEMOTHERAPY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 324 - 330
SICI:
1120-009X(200106)13:3<324:NCFPWS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OSTEOGENIC-SARCOMA; NONMETASTATIC OSTEOSARCOMA; SIMULTANEOUS RESECTION; LUNG METASTASES; METHOTREXATE; EXTREMITIES; CISPLATIN; DIAGNOSIS;
Keywords:
multifocal osteosarcoma; osteosarcoma; synchronous multifocal osteosarcoma; methotrexate; cisplatin; Adriamycin; ifosfamide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Longhi, A Ist Ortoped Rizzoli, Sez Chemioterapia, Dept Chemotherapy, Via Pupilli 1, I-40136 Bologna, Italy Ist Ortoped Rizzoli Via Pupilli 1 BolognaItaly I-40136 , Italy
Citazione:
A. Longhi et al., "Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma: Results in eleven cases", J CHEMOTHER, 13(3), 2001, pp. 324-330

Abstract

Between January 1995 and December 1999, 11 patients with synchronous multifocal osteosarcoma (SMO) received neoadjuvant treatment with high-dose methotrexate, cisplatinum, Adriamycin, and ifosfamide, After primary chemotherapy in 4 patients who had only two bone localizations, it was possible to treat all turner foci locally, The remaining patients, with more than three bones involved, were treated surgically only in 3 cases at the primary site,while secondary lesions did not receive any treatment. The final results of our study were disappointing. All patients died of the tumor 6 to 24 months after the:beginning of treatment (mean 11.9 months). Nevertheless, the survival time of the 4 patients with locally treated lesions was significantly longer than the one of 7 patients in whom the secondary lesions were not locally treated (18.2 vs 9.1 months; P<0.008). It should be noted that those patients simultaneously operated on two sites, the response to chemotherapy of "primary" and "secondary" lesions was always similar, This homogeneity supports the thesis that in synchronous multifocal osteosarcoma the tumors are not multicentric in origin but represent bone-to-bone metastases from a monocentric tumor.

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Documento generato il 07/08/20 alle ore 07:05:23