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Titolo:
Stroke genomics: Approaches to identify, validate, and understand ischemicstroke gene expression
Autore:
Read, SJ; Parsons, AA; Harrison, DC; Philpott, K; Kabnick, K; OBrien, S; Clark, S; Brawner, M; Bates, S; Gloger, I; Legos, JJ; Barone, FC;
Indirizzi:
GlaxoSmithKline, Neurol Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England GlaxoSmithKline Harlow Essex England CM19 5AW ow CM19 5AW, Essex, England GlaxoSmithKline, Neurol Ctr Excellence Bioinformat, Harlow CM19 5AW, Essex, England GlaxoSmithKline Harlow Essex England CM19 5AW ow CM19 5AW, Essex, England GlaxoSmithKline, Neurol Ctr Excellence Genet Res, Harlow CM19 5AW, Essex, England GlaxoSmithKline Harlow Essex England CM19 5AW ow CM19 5AW, Essex, England GlaxoSmithKline, Neurol Ctr Excellence High Throughput Biol, Harlow CM19 5AW, Essex, England GlaxoSmithKline Harlow Essex England CM19 5AW ow CM19 5AW, Essex, England GlaxoSmithKline, King Of Prussia, PA 19406 USA GlaxoSmithKline King Of Prussia PA USA 19406 ing Of Prussia, PA 19406 USA
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 7, volume: 21, anno: 2001,
pagine: 755 - 778
SICI:
0271-678X(200107)21:7<755:SGATIV>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; MESSENGER-RNA EXPRESSION; TRANSIENT FOREBRAIN ISCHEMIA; INTERLEUKIN-1 RECEPTOR ANTAGONIST; SPONTANEOUSLY HYPERTENSIVE RAT; DIFFUSION-WEIGHTED MRI; NECROSIS-FACTOR-ALPHA; REPRESENTATIONAL DIFFERENCE ANALYSIS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDUCED NEUTROPHIL CHEMOATTRACTANT;
Keywords:
differential display; gene expression; MCAO; microarray gridding; neuroprotective genes; neurodestructive genes; protein; representative differential analysis; stroke; stroke in evolution; suppressive subtractive hybridization; target validation; transcription; translation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
201
Recensione:
Indirizzi per estratti:
Indirizzo: Read, SJ GlaxoSmithKline, Neurol Ctr Excellence Drug Discovery, HW2515,NewFrontiers Sci Pk N, Harlow CM19 5AW, Essex, England GlaxoSmithKline HW2515,New Frontiers Sci Pk N Harlow Essex England CM19 5AW
Citazione:
S.J. Read et al., "Stroke genomics: Approaches to identify, validate, and understand ischemicstroke gene expression", J CEREBR B, 21(7), 2001, pp. 755-778

Abstract

Sequencing of the human genome is nearing completion and biologists, molecular biologists, and bioinformatics specialists have teamed up to develop global genomic technologies to help decipher the complex nature of pathophysiologic gene function. This review will focus on differential gene expression in ischemic stroke. It will discuss inheritance in the broader stroke population, how experimental models of spontaneous stroke might be applied tohumans to identify chromosomal loci of increased risk and ischemic sensitivity, and also how the gene expression induced by stroke is related to the poststroke processes of brain injury, repair, and recovery. In addition, wediscuss and summarise the literature of experimental stroke genomics and compare several approaches of differential gene expression analyzes. These in elude a comparison of representational difference analysis we have provided using an experimental stroke model that is representative of stroke evolution observed most often in man, and a summary of available data on strokedifferential gene expression. Issues regarding validation of potential genes as stroke targets, the verification of message translation to protein products, the relevance of the expression of neuroprotective and neurodestructive genes and their Specific timings, and the emerging problems of handling novel genes that may be discovered covered during differential gene expression analyses will also be addressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:33:45