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Titolo:
Reduced anisotropy of action potential conduction in left ventricular hypertrophy
Autore:
Carey, PA; Turner, M; Fry, CH; Sheridan, DJ;
Indirizzi:
Univ Coll London, Inst Urol & Nephrol, London W1W 7EY, England Univ Coll London London England W1W 7EY Nephrol, London W1W 7EY, England St Marys Hosp, Sch Med, Imperial Coll, Div Natl Heart & Lung Inst,Acad Cardiol Unit, London, England St Marys Hosp London England ng Inst,Acad Cardiol Unit, London, England
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 7, volume: 12, anno: 2001,
pagine: 830 - 835
SICI:
1045-3873(200107)12:7<830:RAOAPC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; EPICARDIAL BORDER ZONE; DIRECTIONAL DIFFERENCES; REENTRANT CIRCUITS; CANINE INFARCTS; CARDIAC-MUSCLE; GAP-JUNCTIONS; GUINEA-PIG; MYOCARDIUM; PROPAGATION;
Keywords:
ventricular hypertrophy; arrhythmia mechanism; guinea pig; conduction; membrane biophysics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Fry, CH Univ Coll London, Inst Urol & Nephrol, 48 Riding House St, London W1W 7EY,England Univ Coll London 48 Riding House St London England W1W 7EYngland
Citazione:
P.A. Carey et al., "Reduced anisotropy of action potential conduction in left ventricular hypertrophy", J CARD ELEC, 12(7), 2001, pp. 830-835

Abstract

Introduction: The aim of this study was to determine if anisotropic actionpotential conduction was altered during development of left ventricular hypertrophy (LVH). Methods and Results: Isolated guinea pig left ventricular preparations from hearts that had developed LVH were used to measure conduction velocity inlongitudinal and transverse orientations to the fiber direction. A variable degree of LVH was induced by placing a ring around the ascending aorta for 50 to 250 days, Results were compared,vith an age-matched control group that underwent a similar operation but with no ring placement. LVH was measured as the heart-to-body-weight ratio (HBR), which correlated with an increase of mean myocyte cross-sectional area, Longitudinal conduction velocity (LCV) declined progressively as HER increased (mean +/- SD: sham vs LVH: HBR 3.74 +/- 0.30 g/kg vs 4.53 +/- 0.52 g/kg; LCV 72.8 +/- 15.5 vs 63.6 +/- 11.1 cm/sec), Mean transverse conduction velocity (TCV) was greater in LVH compared with control (20.5 +/- 4.7 cm/sec vs 25.4 +/- 8.1 cm/sec), but there was no significance in the trend as a function of HER. The anisotropic ratio (LCV/TCV) significantly declined as HBR increased. The time constant ofthe foot of the action potential was smaller in the transverse compared with the longitudinal dimension. There was no influence of hypertrophy. Conclusion: The decrease of LCV and reduction of the anisotropic conduction ratio suggest remodeling of the tissue in LVH. The consequences for the generation of arrhythmias are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:06:25