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Titolo:
Endothelin system in human persistent and paroxysmal atrial fibrillation
Autore:
Brundel, BJJM; Van Gelder, IC; Tuinenburg, AE; Wietses, M; Van Veldhuisen, DJ; Van Gilst, WH; Crijns, HJGM; Henning, RH;
Indirizzi:
Univ Groningen Hosp, Thoraxctr, Dept Cardiol, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands rdiol, Groningen, Netherlands Univ Groningen Hosp, Thoraxctr, Dept Clin Pharmacol, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands macol, Groningen, Netherlands
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 7, volume: 12, anno: 2001,
pagine: 737 - 742
SICI:
1045-3873(200107)12:7<737:ESIHPA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; HEART-FAILURE; MECHANISMS; EXPRESSION; VERAPAMIL; RECEPTORS; INCREASE; MYOCYTES; MODEL;
Keywords:
endothelin receptor A; endothelin receptor B; endothelin 1; atrial fibrillation; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Brundel, BJJM Univ Groningen, Dept Clin Pharmacol, Antonius Deusinglaan 1,NL-9713 AV Groningen, Netherlands Univ Groningen Antonius Deusinglaan 1 Groningen Netherlands NL-9713 AV
Citazione:
B.J.J.M. Brundel et al., "Endothelin system in human persistent and paroxysmal atrial fibrillation", J CARD ELEC, 12(7), 2001, pp. 737-742

Abstract

Introduction: Activation of the endothelin system is an important compensatory mechanism that is activated during left ventricular dysfunction, Whether this system plays a role at the atrial level during atrial fibrillation (AF) has not been examined in detail, The purpose of this study was to investigate mRNA and protein expression levels of the endothelin system in AF patients with and without concomitant underlying valve disease. Methods and Results: Right atrial appendages of 36 patients with either paroxysmal or persistent AF were compared with 36 controls in sinus rhythm, The mRNA amounts of pro-endothelin-1 (pro-ET-1), endothelin receptor A (ET-A), and endothelin receptor B (ET-B) were studied by semiquantitative polymerase chain reaction. Protein amounts of the receptors were investigated by slot-blot analysis. mRNA amounts of pro-ET-1 were increased (+40 %; P = 0.002) only in AF patients with underlying valve disease. ET-A and ET-B receptor protein amounts were significantly reduced in patients with paroxysmal AF (-39% and -47%, respectively) and persistent AF,vith underlying valve disease (-28% and -30%, respectively) and in persistent AF without valve disease (-20% and -40%, respectively). ET-A mRNA expression was unaltered in paroxysmal and persistent AF, whereas ET-B mRNA was reduced by 30% in persistent AF with (P < 0.001) or without (P = 0.04) valve disease, but unchanged in paroxysmal AF,Conclusion: Substantial changes in gene expression of the endothelin system were observed in human atria during AF, especially in the presence of underlying valve disease. Alterations in endothelin expression associated withAF could play a role in the pathophysiology of AF and the progression of underlying heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:23:36