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Titolo:
Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits
Autore:
Wu, DJ; Minatoguchi, S; Uno, Y; Arai, M; Wang, NY; Nishida, Y; Hashimoto, K; Hashimoto, Y; Takemura, G; Fujiwara, T; Fujiwara, H;
Indirizzi:
Gifu Univ, Sch Med, Dept Internal Med 2, Gifu 5008705, Japan Gifu Univ Gifu Japan 5008705 d, Dept Internal Med 2, Gifu 5008705, Japan Chung Shan Med & Dent Coll Hosp, Dept Internal Med, Taichung, Taiwan ChungShan Med & Dent Coll Hosp Taichung Taiwan l Med, Taichung, Taiwan Kyoto Womens Univ, Kyoto, Japan Kyoto Womens Univ Kyoto JapanKyoto Womens Univ, Kyoto, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 7, volume: 65, anno: 2001,
pagine: 673 - 677
SICI:
0047-1828(200107)65:7<673:CONAIP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOGEN DEPLETION; ENERGY-METABOLISM; RAT-HEART; PROTECTION; INHIBITION; RECOVERY; ENZYME; DAMAGE;
Keywords:
ischemia; glycogen; myocardial infarction; myocardium; alpha-glucosidase inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Fujiwara, H Gifu Univ, Sch Med, Dept Internal Med 2, 40 Tsukasa Machi, Gifu 5008705, Japan Gifu Univ 40 Tsukasa Machi Gifu Japan 5008705 5008705, Japan
Citazione:
D.J. Wu et al., "Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits", JPN CIRC J, 65(7), 2001, pp. 673-677

Abstract

N-methyl-1-deoxynojirimycin (NMDN), an alpha -glucosidase inhibitor, reduces myocardial infarct size by reducing the glycogenolytic rate through inhibition of the alpha -1,6-glucosidase of glycogen-debranching enzyme in the heart, in addition to possessing an antihyperglycemic action by blocking alpha -1,4-glucosidase in the intestine. Ischemic preconditioning (PC), whichmarkedly reduces the size of the myocardial infarct, is known to reduce the activity of phosphorylase and reduce the glycogenolytic rate. Therefore, it was hypothesized that a combination of pharmacological inhibition of glycogenolysis by an alpha -1,6-glucosidase inhibitor, NMDN, and PC could markedly reduce myocardial infarct size more than NMDN or PC alone. Japanese white rabbits without collateral circulation were subjected to a 30-min coronary occlusion followed by 48-h reperfusion. The infarct sizes as a percentage of area at risk were significantly reduced by pre-ischemic treatment with either 100 mg/kg of NMDN or PC of 5 min ischemia and 5 min reperfusion alone (15.9 +/-2.0%, n=8, and 10.3 +/-1.21%, n=8, respectively) as compared with the control (43.9 +/-2.2%, n=8). However, the combination of 100 mg/kg of NMDN and PC significantly reduced the infarct size (4.9 +/-1.2, n=8) compared with NMDN or PC alone. Another 40 rabbits, also given 100 mg of NMDN,PC, NMDN + PC or saline before ischemia (n=10 in each group), were killed for biochemical analysis after 30 min of ischemia. NMDN and PC preserved the glycogen content and attenuated the lactate accumulation, respectively, as compared with the control. However, the combination of NMDN and PC preserved significantly more glycogen and significantly reduced lactate accumulation than either NMDN or PC alone. The combination of NMDN and PC markedly reduced the myocardial infarct size more than either process alone. The marked preservation of glycogen and marked attenuation of lactate accumulation by the combination of NMDN and PC suggest that the mechanism for this effect of NMDN+PC is related to the inhibition of glycogenolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:02:01