Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Occurrence of serious adverse effects in patients receiving community-based therapy for multidrug-resistant tuberculosis
Autore:
Furin, JJ; Mitnick, CD; Shin, SS; Bayona, J; Becerra, MC; Singler, JM; Alcantara, F; Castaneda, C; Sanchez, E; Acha, J; Farmer, PE; Kim, JY;
Indirizzi:
Harvard Univ, Sch Med, Dept Social Med, Program Infect Dis & Social Change, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 is & Social Change, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Populat & Int Hlth, Boston, MA 02115 USAHarvard Univ Boston MA USA 02115 Populat & Int Hlth, Boston, MA 02115 USA Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA Socios Salud Sucuras Peru, Partners Hlth, Carabayllo, Peru Socios Salud Sucuras Peru Carabayllo Peru rtners Hlth, Carabayllo, Peru Natl TB Program, Lima, Peru Natl TB Program Lima PeruNatl TB Program, Lima, Peru Hosp Sergio E Bernales, Comas, Peru Hosp Sergio E Bernales Comas PeruHosp Sergio E Bernales, Comas, Peru
Titolo Testata:
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
fascicolo: 7, volume: 5, anno: 2001,
pagine: 648 - 655
SICI:
1027-3719(200107)5:7<648:OOSAEI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-COURSE CHEMOTHERAPY; PULMONARY TUBERCULOSIS; ANTITUBERCULOSIS DRUGS; OUTCOMES; MANAGEMENT; TOXICITY; AMINOGLYCOSIDES; REGIMENS;
Keywords:
tuberculosis; antimicrobial resistance; adverse effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Furin, JJ Harvard Univ, Sch Med, Dept Social Med, Program Infect Dis & Social Change, 641 Huntington, Boston, MA 02115 USA Harvard Univ 641 Huntington Boston MA USA 02115 on, MA 02115 USA
Citazione:
J.J. Furin et al., "Occurrence of serious adverse effects in patients receiving community-based therapy for multidrug-resistant tuberculosis", INT J TUBE, 5(7), 2001, pp. 648-655

Abstract

SETTING: A community-based treatment program for multidrug-resistant tuberculosis (MDR-TB) in an urban shantytown of Lima, Peru. OBJECTIVES: To ascertain the occurrence of serious adverse effects associated with therapy for MDR-TB in northern Lima, Peru, where therapy was individualized according to drug-susceptibility testing of patients' infecting strains and delivered through a community-based program. DESIGN: A retrospective record review of 60 patients who had received individualized therapy for MDR-TB between September 1996 and October 1998. RESULTS: Although adverse effects were common, they occurred less frequently than previously reported in the literature and were rarely life-threatening. Effects occurring most frequently in this population included: mild gastritis (100%), dermatological effects (43.3%), peripheral neuropathy (16.7%), depression (18.3%), and anxiety (11.7%). These effects never resulted in the discontinuation of anti-tuberculosis therapy, and only occasionally resulted in the suspension of an agent (11.7%). CONCLUSION: In young patients with little comorbid disease, multidrug, long-course regimens rarely caused life-threatening adverse effects. Common side effects may be managed successfully on an out-patient basis through a community-based treatment program in conjunction with MDR-TB experts, even inresource-poor settings. The very low rate of default in this cohort offershope that strategies to manage the adverse effects may reduce the incidence of abandonment of therapy and increase rates of cure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:20:35