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Titolo:
Investigation of tuberculosis transmission in Canadian Arctic Inuit Communities using DNA fingerprinting
Autore:
Kunimoto, D; Chedore, P; Allen, R; Kasatiya, S;
Indirizzi:
Univ Alberta, Dept Med, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada Alberta, Dept Med, Edmonton, AB, Canada Ontario Minist Hlth & Long Term Care, Lab Branch, Etobicoke, ON, Canada Ontario Minist Hlth & Long Term Care Etobicoke ON Canada oke, ON, Canada Baffin Reg Hlth Board, Iqaluit, NT, Canada Baffin Reg Hlth Board Iqaluit NT Canada Hlth Board, Iqaluit, NT, Canada Univ Ottawa, Dept Microbiol & Immunol, Ottawa, ON, Canada Univ Ottawa Ottawa ON Canada ept Microbiol & Immunol, Ottawa, ON, Canada
Titolo Testata:
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
fascicolo: 7, volume: 5, anno: 2001,
pagine: 642 - 647
SICI:
1027-3719(200107)5:7<642:IOTTIC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-TUBERCULOSIS; EPIDEMIOLOGY; POPULATION; STRAINS; TOOL;
Keywords:
tuberculosis; DNA fingerprinting; cluster analysis; epidemiology; molecular;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kunimoto, D Univ Alberta Hosp, Walter Mackenzie Ctr 2E4 11, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 T6G 2B7, Canada
Citazione:
D. Kunimoto et al., "Investigation of tuberculosis transmission in Canadian Arctic Inuit Communities using DNA fingerprinting", INT J TUBE, 5(7), 2001, pp. 642-647

Abstract

OBJECTIVE: To understand the transmission of tuberculosis in Inuit communities in the Baffin region of the Canadian Arctic. METHODS: Twenty-one isolates of Mycobacterium tuberculosis from 19 Inuit patients diagnosed with tuberculosis between February 1991 and September 1993 were analyzed bq DNA fingerprinting. The DNA fingerprints were achieved by the standard restriction fragment length polymorphism (RFLP) technique, with subsequent probing using the repetitive insertion segment IS6110. RESULTS: The isolates could be divided into three DNA types. The DNA typesgenerally corresponded to the geographic origins of the patients. In most instances only one DNA type of M. tuberculosis was identified in each community. This suggests that a single case was the start of each of the three clusters, most likely due to reactivation. CONCLUSIONS: The results show that molecular typing of M. tuberculosis wasuseful in determining the mode of transmission of tuberculosis in a remotearea of the Canadian Arctic where the disease is endemic. In addition, theinformation provides useful information for planning interventions in thissetting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:35:26