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Titolo:
Circulating dopamine level, in lung carcinoma patients, inhibits proliferation and cytotoxicity of CD4+and CD8+T cells by D1 dopamine receptors: an in vitro analysis
Autore:
Saha, B; Mondal, AC; Basu, S; Dasgupta, PS;
Indirizzi:
Chittaranjan Natl Canc Inst, Signal Transduct & Biogen Amines Lab, Calcutta 700026, W Bengal, India Chittaranjan Natl Canc Inst Calcutta W Bengal India 700026 Bengal, India Chittaranjan Natl Canc Inst, Dept Med Oncol, Calcutta 700026, W Bengal, India Chittaranjan Natl Canc Inst Calcutta W Bengal India 700026 Bengal, India
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 7, volume: 1, anno: 2001,
pagine: 1363 - 1374
SICI:
1567-5769(200107)1:7<1363:CDLILC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-LYMPHOCYTES; BEARING MICE; STRESS; PROTEIN; PLASMA; CATECHOLAMINES; EXPRESSION; CANCER; DEPRESSION; IMMUNITY;
Keywords:
dopamine; receptor; proliferation; lymphocytes; malignancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Dasgupta, PS Chittaranjan Natl Canc Inst, Signal Transduct & Biogen AminesLab, Res Bldg,37 SP Mukherjee Rd, Calcutta 700026, W Bengal, India Chittaranjan Natl Canc Inst Res Bldg,37 SP Mukherjee Rd Calcutta W Bengal India 700026
Citazione:
B. Saha et al., "Circulating dopamine level, in lung carcinoma patients, inhibits proliferation and cytotoxicity of CD4+and CD8+T cells by D1 dopamine receptors: an in vitro analysis", INT IMMUNO, 1(7), 2001, pp. 1363-1374

Abstract

Besides cardiovascular and renal functions, the role of dopamine in periphery as an endogenous regulator of immune functions is in the limelight. in human malignancy. depression of T cell functions is known. Interestingly, recent evidences indicate significant elevation of plasma dopamine in malignancy due to stress of the disease process. Therefore, this study evaluates whether this increased plasma dopamine exerts any influence on the proliferation and cytotoxicity of CD4 + and CD8 + T cells. Patients with lung carcinoma were selected for this study due to the high prevalence rate of this kind of cancer in developing countries and also due to strong positive biochemical and psychological criteria of stress in most of the patients. Results showed significant elevation of plasma dopamine (48.6 +/- 5.1 pg/ml) in lung cancer patients than normal controls (10.2 +/- 0.9 pg/ml). In vitro dopamine concentration, simulating the plasma concentration of the patients, significantly inhibited the proliferation and cytotoxicity of T cells of these patients and also of the normal volunteers, in presence of their respective serum. The mechanism has been attributed to be D1 class of dopamine receptor mediated elevation of intracellular cAMP in these cell populations. The results may be of significance in understanding the role of peripheral dopamine as an immunomodulator in human health and diseases. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:46:06