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Titolo:
Signal transduction pathways in directed migration of human monocytes induced by human growth hormone in vitro
Autore:
Kahler, CM; Pischel, AB; Haller, T; Meierhofer, C; Djanani, A; Kaufmann, G; Wiedermann, CJ;
Indirizzi:
Innsbruck Univ, Fac Med, Dept Gen Internal Med, ICU Lab, A-6020 Innsbruck,Austria Innsbruck Univ Innsbruck Austria A-6020 CU Lab, A-6020 Innsbruck,Austria Innsbruck Univ, Fac Med, Dept Gen Internal Med, Serv Pneumol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 eumol, A-6020 Innsbruck, Austria Innsbruck Univ, Fac Med, Inst Physiol, A-6020 Innsbruck, Austria InnsbruckUniv Innsbruck Austria A-6020 ysiol, A-6020 Innsbruck, Austria
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 7, volume: 1, anno: 2001,
pagine: 1351 - 1361
SICI:
1567-5769(200107)1:7<1351:STPIDM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE PHOSPHORYLATION; HUMAN NEUTROPHILS; RECEPTOR; INVOLVEMENT; STIMULATION; WORTMANNIN; CHEMOTAXIS; KINASE; CELLS; GENE;
Keywords:
human growth hormone; monocytes; signalling; protein kinase C; calcium; tyrosinkinase; staurosporine; tyrphostin; wortmannin; G-protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Wiedermann, CJ Innsbruck Univ, Fac Med, Dept Gen Internal Med, ICU Lab, Anichstr 35, A-6020 Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 ustria
Citazione:
C.M. Kahler et al., "Signal transduction pathways in directed migration of human monocytes induced by human growth hormone in vitro", INT IMMUNO, 1(7), 2001, pp. 1351-1361

Abstract

The human growth hormone (GH) was shown to modulate leukocyte functions such as stimulating directed migration of human monocytes in vitro, Dimerisation of OH-receptors leads to the activation of various signalling mechanisms. As transduction of GH signals to monocytes is unknown. we investigated GH signalling mechanisms in monocyte migration using a modified Boyden chamber chemotaxis assay. Inhibition of tyrosyl phosphorylation of OH receptor-associated tyrosine kinase by tyrphostin-23 or staurosporine blocked OH-stimulated monocyte migration down to random levels. Furthermore. pre-incubation with effective concentrations of 4B-phorbol-12-myristate-13-acetate (PMA). staurosporine and bisindolymaleimide I. inhibitors of protein kinase C. significantly decreased OH-induced migration, suggesting that PKC is involved in the signalling cascade. Additionally. phosphatidylinositol 3-kinase and mitogen-activated protein kinase (MAPK) activation seems to be required. This study revealed signalling pathways in monocyte movement toward GH in vitro. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 04/04/20 alle ore 11:22:08