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Titolo:
Development of immunoadjuvants for immunotherapy of cancer
Autore:
Azuma, I; Seya, T;
Indirizzi:
Hakodate Natl Coll Technol, Hakodate, Hokkaido 0428501, Japan Hakodate Natl Coll Technol Hakodate Hokkaido Japan 0428501 0428501, Japan Osaka Med Ctr Canc & Cardiovasc Dis, Dept Immunol, Higashinari, Osaka 5370025, Japan Osaka Med Ctr Canc & Cardiovasc Dis Higashinari Osaka Japan 5370025 Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 7, volume: 1, anno: 2001,
pagine: 1249 - 1259
SICI:
1567-5769(200107)1:7<1249:DOIFIO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-WALL SKELETON; TOLL-LIKE RECEPTOR-2; MURAMYL DIPEPTIDE; T-CELLS; STRUCTURAL REQUIREMENTS; ADJUVANT IMMUNOTHERAPY; INTERFERON-GAMMA; VIRUS-INFECTION; DROSOPHILA TOLL; DENDRITIC CELLS;
Keywords:
mycobacterial cell fractions; cell wall skeleton (CWS); cancer immunotherapy; MDP; TDM; CpG repeats; dendritic cells/macrophages; toll-like receptor; innate immunity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Seya, T Osaka Med Ctr Canc & Cardiovasc Dis, Dept Immunol, 1-3-3 Nakamichi, Higashinari, Osaka 5370025, Japan Osaka Med Ctr Canc & Cardiovasc Dis 1-3-3 Nakamichi Higashinari Osaka Japan 5370025
Citazione:
I. Azuma e T. Seya, "Development of immunoadjuvants for immunotherapy of cancer", INT IMMUNO, 1(7), 2001, pp. 1249-1259

Abstract

Previously, we have reported that cell-wall skeleton (CWS) fraction was the major adjuvant-active principle of mycobacterial cells which were used inFreund's complete adjuvant (FCA). We have described the biochemical and immunological properties of CWS of mycobacteria and related bacteria, especially the CWS of Mycobacterium boeis BCG strain (BCG-CWS) in derail. The effectiveness of BCG-CWS for the cancer immunotherapy in patients was shown in several clinical trials. On the action mechanism of BCG-CWS on host immune cells, we have suggested that dendritic cells and macrophages express two sorts of receptors, Toll-like receptors, TLR-2 and TLR-4, and a putative binding receptor for BCG-CWS, whose signaling pathways lead to a sufficient antigen-presenting state in the activation of the innate immune system. We have also reported the usefulness of synthetic immunoadjuvants such as muramyldipeptide (MDP) derivatives, trehalose-dimycolates (TDM) and DNA fraction for the application for the cancer and infectious diseases in experimental systems and cancer patients. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 00:21:29