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Titolo:
Allopurinol augmentation for poorly responsive schizophrenia
Autore:
Lara, DR; Brunstein, MG; Ghisolfi, ES; Lobato, MI; Belmonte-de-Abreu, P; Souza, DO;
Indirizzi:
UFRGS, ICBS, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil UFRGS Porto Alegre RS Brazil BR-90035003 BC35003 Porto Alegre, RS, Brazil PUC RS, Fac Biosci, Dept Biochem, Porto Alegre, RS, Brazil PUC RS Porto Alegre RS Brazil ci, Dept Biochem, Porto Alegre, RS, Brazil UFRGS, HCPA, Dept Psychiat, Porto Alegre, RS, Brazil UFRGS Porto Alegre RS Brazil PA, Dept Psychiat, Porto Alegre, RS, Brazil
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 16, anno: 2001,
pagine: 235 - 237
SICI:
0268-1315(200107)16:4<235:AAFPRS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONISTS; NEGATIVE SYMPTOMS; DOUBLE-BLIND; LAMOTRIGINE; BEHAVIOR; STRIATUM; MODEL;
Keywords:
allopurinol; adenosine; purinergic system; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lara, DR UFRGS, ICBS, Dept Bioquim, Rua Ramiro Barcelos,2600 Anexo, BR-90035003 Porto Alegre, RS, Brazil UFRGS Rua Ramiro Barcelos,2600 Anexo Porto Alegre RS Brazil BR-90035003 BC
Citazione:
D.R. Lara et al., "Allopurinol augmentation for poorly responsive schizophrenia", INT CLIN PS, 16(4), 2001, pp. 235-237

Abstract

Adenosine has been proposed to contribute to the pathophysiology of schizoprenia and as a target for therapeutic intervention. In the lack of direct adenosine agonists, allopurinol may indirectly elevate adenosine levels by inhibiting degradation of purines. We report two cases of poorly responsiveschizophrenic patients who improved considerably with add-on allopurinol 300 mg / day. Their clear clinical improvement warrant further investigationof allopurinol, as well as other purinergic strategies, for the treatment of schizophrenia. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:21:11