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Titolo:
Olanzapine in the treatment of post-traumatic stress disorder: a pilot study
Autore:
Butterfield, MI; Becker, ME; Connor, KM; Sutherland, S; Churchill, LE; Davidson, JRT;
Indirizzi:
Durham Vet Adm Med Ctr, Dept Psychiat 116A, Durham, NC 27705 USA Durham Vet Adm Med Ctr Durham NC USA 27705 iat 116A, Durham, NC 27705 USA Duke Univ, Med Ctr, Dept Psychiat & Behav Med, Durham, NC USA Duke Univ Durham NC USA d Ctr, Dept Psychiat & Behav Med, Durham, NC USA
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 16, anno: 2001,
pagine: 197 - 203
SICI:
0268-1315(200107)16:4<197:OITTOP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC DRUG; RANDOMIZED CONTROLLED TRIAL; SERTRALINE TREATMENT; RATING-SCALE; DOUBLE-BLIND; PLACEBO; PHARMACOTHERAPY; RISPERIDONE; IMIPRAMINE; NEFAZODONE;
Keywords:
atypical antipsychotic; olanzapine; post-traumatic stress disorder (PTSD); psychopharmacology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Butterfield, MI Durham Vet Adm Med Ctr, Dept Psychiat 116A, 508 Fulton St,Durham, NC 27705 USA Durham Vet Adm Med Ctr 508 Fulton St Durham NC USA 27705 A
Citazione:
M.I. Butterfield et al., "Olanzapine in the treatment of post-traumatic stress disorder: a pilot study", INT CLIN PS, 16(4), 2001, pp. 197-203

Abstract

Because the atypical antipsychotic olanzapine may be efficacious in treating post-traumatic stress disorder (PTSD) symptoms, we conducted a 10-week, double-blind, placebo-controlled evaluation in which 15 patients were randomized 2 : 1 to either olanzapine or placebo. The initial dosage was 5 mg / day and was titrated to a maximum of 20 mg / day. Eleven patients completedthe study, Patients in both groups showed improvement in PTSD symptoms, but no between-group differences in treatment response were observed and a high placebo response rate was found. Both treatments were tolerated well, although the olanzapine treatment group had more weight gain. Olanzapine fared no better than placebo in this preliminary study In the treatment of PTSD, The lack of difference between olanzapine and placebo may in part be due to olanzapine's not being effective in PTSD or, alternatively, a small sample size, a high placebo response in certain forms of PTSD and the chronicity of PTSD symptoms in some patients. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 21/01/20 alle ore 01:50:20