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Titolo:
Technetium(V) oxo complexes of substituted propylene diamine dioxime (PnAO) ligands: Water-dependent interconversion between Syn and anti isomers
Autore:
Cyr, JE; Nowotnik, DP; Pan, Y; Gougoutas, JZ; Malley, MF; Di Marco, J; Nunn, AD; Linder, KE;
Indirizzi:
Bracco Res USA, Princeton, NJ 08540 USA Bracco Res USA Princeton NJ USA 08540 co Res USA, Princeton, NJ 08540 USA Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08453 USA Bristol Myers Squibb Co Princeton NJ USA 08453 t, Princeton, NJ 08453 USA
Titolo Testata:
INORGANIC CHEMISTRY
fascicolo: 14, volume: 40, anno: 2001,
pagine: 3555 - 3561
SICI:
0020-1669(20010702)40:14<3555:TOCOSP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY STRUCTURE; IMAGING AGENTS; TC-99M; NITROIMIDAZOLE; RHENIUM(V); PERFUSION; CHELATOR; HYPOXIA; THIOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Cyr, JE Diatide Inc, 9 Delta Dr, Londonderry, NH 03053 USA Diatide Inc 9 Delta Dr Londonderry NH USA 03053 erry, NH 03053 USA
Citazione:
J.E. Cyr et al., "Technetium(V) oxo complexes of substituted propylene diamine dioxime (PnAO) ligands: Water-dependent interconversion between Syn and anti isomers", INORG CHEM, 40(14), 2001, pp. 3555-3561

Abstract

Tc-99m and Tc-99 complexes of PnAO (propylene diamine dioxime) ligands monosubstituted in the B-position [PnAO-6-R] were prepared and studied. Ligands substituted with an alkyl group or with no substituent (R = H, CH3, or CH2CH(CH3)(2)), gave only one Tc complex. However, for several other nonalkylsubstituents (R = COOCH3, OH, OCH3, OCH2CH3, F, CN, NHCOCH3, and NHCOCH2CH3), two Tc complexes A and B were formed. Products A and B were assigned tothe anti and syn TcO(PnAO-6-R) species, respectively, based on H-1 NMR results. X-ray structure analyses supported these assignments. The A (anti) isomer of. TcO(PnAO-6-OH) had the chemical formula TcC13H25N4O4 and crystallized in an orthorhombic system with space group P2(1)2(1)2(1) and Z = 4; a =12.744(2) Angstrom, b = 13.591(2) Angstrom, c = 9.976(2) Angstrom. The B (syn) isomer of TcO(PnAO-6-CN) had the chemical formula TcC14H24N5O3 and wasa 1:4 mixture of two monoclinic polymorphs: individual rectangular prisms (space group P2(1)/c, Z = 4) and clusters of intergrown twinned rectangularrods (space group Cc, Z = 8). For the prisms, a 12.457(1) Angstrom, b = 13.932(1) Angstrom, c 10.336(1) Angstrom, and for the rods, a = 31.344(5) Angstrom, b = 6.993(1) Angstrom, c = 21.657(2) Angstrom. The syn and anti isomers interconverted in the presence of water; nonequilibrium mixtures of epimers remained unchanged under dry conditions. The HPLC behavior under reversed phase conditions was consistent with on-column interconversion (poor resolution), whereas the two isomers were cleanly resolved under drier normalphase conditions. An oro inversion mechanism involving trans water attack is proposed for the interconversion process. Water also influenced the position of equilibrium of the two isomers. The syn isomer was stabilized ill water relative to the anti isomer.

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Documento generato il 30/03/20 alle ore 12:26:46