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Titolo:
Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4
Autore:
Panasiuk, A; Prokopowicz, D; Zak, J; Matowicka-Karna, J; Osada, J; Wysocka, J;
Indirizzi:
Med Acad Bialystok, Dept Infect Dis, PL-15523 Bialystok, Poland Med Acad Bialystok Bialystok Poland PL-15523 PL-15523 Bialystok, Poland Med Acad Bialystok, Dept Lab Pediat Diagnost, Bialystok, Poland Med Acad Bialystok Bialystok Poland Pediat Diagnost, Bialystok, Poland Med Acad Bialystok, Dept Clin Diagnost, Bialystok, Poland Med Acad Bialystok Bialystok Poland pt Clin Diagnost, Bialystok, Poland Med Acad Bialystok, Dept Hematol Diagnost, Bialystok, Poland Med Acad Bialystok Bialystok Poland Hematol Diagnost, Bialystok, Poland
Titolo Testata:
HEPATO-GASTROENTEROLOGY
fascicolo: 39, volume: 48, anno: 2001,
pagine: 818 - 822
SICI:
0172-6390(200105/06)48:39<818:AOBPIC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; ADHESION; MECHANISM; MOLECULE; NECROSIS; DISEASE; CELLS;
Keywords:
blood platelets; liver diseases; P-selectin; beta-thromboglobulin; platelet factor 4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Panasiuk, A Med Acad Bialystok, Dept Infect Dis, 14 Zurawia St, PL-15523 Bialystok, Poland Med Acad Bialystok 14 Zurawia St Bialystok Poland PL-15523 nd
Citazione:
A. Panasiuk et al., "Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4", HEP-GASTRO, 48(39), 2001, pp. 818-822

Abstract

Background/Aims: Blood platelets-are;cells that quite often undergo damagein chronic liver diseases. Endotoxemia and hyperkinetic circulation influence platelets in an active manner. The role sf platelets in the developmentof hepatitis and liver fibrosis is speculative. The aim of the study was to determine the influence of chronic liver diseases on platelets morphologic parameters, their secretory activity and beta -selectin expression. Methodology: The examination-was completed in the group of 29 patients with chronic hepatitis and 27 with liver cirrhosis of postinflammatory etiology (HBV HCV); Liver biopsies were carried out in all control group. Platelets morphological parameters (number, volume,platelet crit, micro- and macro-thrombocyte fraction) were estimated. beta -thromboglobulin concentration and platelet:factor 4 in blood serum as well as beta -selectin expression onresting platelets and after thrombin activation were alsoexamined. Results:Number, volume, and platelet crit decreased with the advancement of a liver disease. Megathrombocyte fraction increased inversely with the severity of liver damage. The concentration of beta -thromboglobulin and platelet factor 4 alpha -granule contents in blood serum was higher 2- and 7-times, respectively than in healthy controls. beta -selectin expression on resting platelets was considerably higher. After stimulation with thrombin, beta -selectin expression was equal (chronic hepatitis) or: higher (liver cirrhosis)than in the control. Conclusions: There are changes of platelet megathrombocyte fraction increase, that occur in chronic liver diseases. Thrombocytes in chronic liver diseases and Liver cirrhosis are more activated. Platelet-sensitivity to stimuli in these ailments is higher (liver cirrhosis) than in the healthy controls.

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Documento generato il 21/01/20 alle ore 07:34:15