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Titolo:
Evaluation of hepatic functional reserve in rats with obstructive jaundiceby asyaloglycoprotein receptor
Autore:
Mimura, T; Hamazaki, K; Sakai, H; Tanaka, N; Mimura, H;
Indirizzi:
Okayama Univ, Sch Med, Dept Surg 1, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Surg 1, Okayama 7008558, Japan
Titolo Testata:
HEPATO-GASTROENTEROLOGY
fascicolo: 39, volume: 48, anno: 2001,
pagine: 777 - 782
SICI:
0172-6390(200105/06)48:39<777:EOHFRI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASIALOGLYCOPROTEIN RECEPTOR; LIVER; CIRRHOSIS; INSULIN;
Keywords:
(TC)-T-99m-galactosyl-human serum albumin ((99)mTc-GSA); asyaloglyco-protein-receptor (ASG-R); obstructive jaundice; liver functional reserve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hamazaki, K Okayama Univ, Sch Med, Dept Surg 1, 2-5-1 Shikata Cho, Okayama7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8, Japan
Citazione:
T. Mimura et al., "Evaluation of hepatic functional reserve in rats with obstructive jaundiceby asyaloglycoprotein receptor", HEP-GASTRO, 48(39), 2001, pp. 777-782

Abstract

Background/Aims: Until now, there has been no adequate means of evaluatingthe liver functional reserve in cases with obstructive jaundice, (TC)-T-99m-GSA ((99m)Technetium-DTPA- Galactosyl-human serum albumin) is a new liver-imaging agent which binds specifically to the asyaloglycoprotein-receptor on the membrane of hepatocytes. So, the liver imaging by GSA excludes the influence of the reticuloendothelial system. Therefore, the uptake of (TC)-T-99m-GSA is considered to be a useful method for the estimation of liver functional reserve in cases with obstructive jaundice. Methodology: In this study, we examined the uptake rate and specific binding capacities of (TC)-T-99m-GSA to receptors on the membrane of hepatocytesfollowing 1, and 2 weeks of bile-duct ligation and 1 week. after reductionof jaundice using the rat model. Results: The hepatic uptake rate decreased as the period of jaundice was prolonged and returned to nearly normal by the reduction of jaundice. The value of specific binding capacities at 2 weeks after bile-duct ligation decreased significantly compared to the value of the control and the reduced group (P <0.05). The cause of decrease in specific binding capacities was indicated as the decrease of affinity constant especially in the high affinitypart. These results coincide with the change of binding capacities of insulin and glucagon receptors with obstructive jaundice, which accurately reflect the severity of hepatocyte injury. Conclusions: Taking together these results, (TC)-T-99m-GSA liver scintigraphy is thought to be a useful method to evaluate the liver functional reserve in cases with jaundice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 12:44:05