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Titolo:
Visual cortex excitability in migraine with and without aura
Autore:
Mulleners, WM; Chronicle, EP; Palmer, JE; Koehler, PJ; Vredeveld, JW;
Indirizzi:
Atrium Med Ctr, Dept Neurol, NL-6401 CX Heerlen, Netherlands Atrium Med Ctr Heerlen Netherlands NL-6401 CX 01 CX Heerlen, Netherlands Atrium Med Ctr, Dept Clin Neurophysiol, NL-6401 CX Heerlen, Netherlands Atrium Med Ctr Heerlen Netherlands NL-6401 CX 01 CX Heerlen, Netherlands Univ Lancaster, Mental Hlth & Neural Syst Res Unit, Lancaster LA1 4YW, England Univ Lancaster Lancaster England LA1 4YW nit, Lancaster LA1 4YW, England
Titolo Testata:
HEADACHE
fascicolo: 6, volume: 41, anno: 2001,
pagine: 565 - 572
SICI:
0017-8748(200106)41:6<565:VCEIMW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL MAGNETIC STIMULATION; INTERICTAL CORTICAL EXCITABILITY; FAMILIAL HEMIPLEGIC MIGRAINE; RESONANCE SPECTROSCOPY; EVOKED POTENTIALS; ENERGY-METABOLISM; OCCIPITAL CORTEX; BRAIN; HYPEREXCITABILITY; DYSFUNCTION;
Keywords:
migraine; hyperexcitability; magnetic stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Mulleners, WM Atrium Med Ctr, Dept Neurol, POB 4446, NL-6401 CX Heerlen, Netherlands Atrium Med Ctr POB 4446 Heerlen Netherlands NL-6401 CX ands
Citazione:
W.M. Mulleners et al., "Visual cortex excitability in migraine with and without aura", HEADACHE, 41(6), 2001, pp. 565-572

Abstract

Objectives.-Previous research using transcranial magnetic stimulation has produced equivocal findings concerning thresholds for the generation of visual phosphenes in migraine with aura. These studies were methodologically varied and did not systematically address cortical excitability in migraine without aura. We therefore studied magnetophosphene thresholds in both migraine with aura and migraine without aura compared with headache-free controls. Methods.-Sixteen subjects with migraine with aura and 12 subjects with migraine without aura were studied and compared with 16 sex- and age-matched controls. Using a standardized transcranial magnetic stimulation protocol ofthe occipital cortex, we assessed the threshold stimulation intensity at which subjects just perceived phosphenes via a method of alternating course and fine-tuning of stimulator output. Results.-There were no significant differences across groups in the proportion of subjects seeing phosphenes, However, the mean threshold at which phosphenes were reported was significantly lower in both migraine groups (migraine with aura=47%, migraine without aura=46%) than in controls (66%), Moreover, there was no significant correlation between individual phosphene threshold and the time interval to the closest migraine attack. Conclusion.-Our findings confirm that the occipital cortex is hyperexcitable in the migraine interictum, both in migraine with and without aura.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:25:47