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Titolo:
Regulation of gastric function by endogenous gastrin releasing peptide in humans: studies with a specific gastrin releasing peptide receptor antagonist
Autore:
Hildebrand, P; Lehmann, FS; Ketterer, S; Christ, AD; Stingelin, T; Beltinger, J; Gibbons, AH; Coy, DH; Calam, J; Larsen, F; Beglinger, C;
Indirizzi:
Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland Univ Basel Hosp, Dept Res, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 es, CH-4031 Basel, Switzerland Tulane Univ, Med Ctr, Peptide Res Labs, Dept Med, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 Dept Med, New Orleans, LA 70112 USA Ipsen Int Ltd, London W8 5HH, England Ipsen Int Ltd London England W8 5HH psen Int Ltd, London W8 5HH, England Hammersmith Hosp, Div Med, London W12 0NN, England Hammersmith Hosp London England W12 0NN Div Med, London W12 0NN, England
Titolo Testata:
GUT
fascicolo: 1, volume: 49, anno: 2001,
pagine: 23 - 28
SICI:
0017-5749(200107)49:1<23:ROGFBE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-SECRETION; BOMBESIN; RAT; INHIBITION; POTENCY; NEURONS; FUNDUS; ANALOG; CELLS;
Keywords:
gastrin; gastric acid secretion; gastrin releasing peptide; gastric function; BIM26226;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Beglinger, C Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 asel, Switzerland
Citazione:
P. Hildebrand et al., "Regulation of gastric function by endogenous gastrin releasing peptide in humans: studies with a specific gastrin releasing peptide receptor antagonist", GUT, 49(1), 2001, pp. 23-28

Abstract

Background and aims-The main goal of our study was to characterise the activity of BIM26226 as a peripheral gastrin releasing peptide (GRP) receptor antagonist in healthy human subjects and to determine if endogenous GRP is a physiological regulator of gastric acid secretion and gastrin release. Methods-Our study consisted of three parts. In part I, subjects received saline or BIM26226 followed by graded doses of intravenous human GRP in a four period crossover design. In part II, subjects received BIM26226 or saline during oral meal ingestion or modified sham feeding. In part III, subjects received an acidified meal in the presence and absence of BIM26226 in a two period crossover design. In addition, gastrin and somatostatin mRNA weremeasured in biopsy specimens during saline and BIM26226 infusion. Results-BIM26226 dose dependently inhibited GRP induced acid output. Acid secretion after oral liquid meal intake and sham feeding was significantly inhibited by BIM26226 (p<0.01) whereas plasma gastrin release remained unchanged. Gastrin and somatostatin mRNAs were not significantly different after saline or BIM26226. Conclusions-BIM26226 is a potent GRP antagonist in humans. Endogenous GRP may be a physiological regulator of gastric acid secretion. Gastrin releasedoes not seem to be under the control of GRP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:31:07