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Titolo:
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
Autore:
Lue, LF; Rydel, R; Brigham, EF; Yang, LB; Hampel, H; Murphy, GM; Brachova, L; Yan, SD; Walker, DG; Shen, Y; Rogers, J;
Indirizzi:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst Sun City AZ USA 85372 Res Inst, Sun City, AZ 85372 USA Elan Pharmaceut, S San Francisco, CA USA Elan Pharmaceut S San Francisco CA USA armaceut, S San Francisco, CA USA Univ Munich, Dept Psychiat, Dementia Res Sect, D-8000 Munich, Germany UnivMunich Munich Germany D-8000 entia Res Sect, D-8000 Munich, Germany Univ Munich, Memory Clin, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 h, Memory Clin, D-8000 Munich, Germany Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Neurosci Res Labs, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 osci Res Labs, Stanford, CA 94305 USA Columbia Univ, Dept Pathol, New York, NY USA Columbia Univ New York NY USA lumbia Univ, Dept Pathol, New York, NY USA
Titolo Testata:
GLIA
fascicolo: 1, volume: 35, anno: 2001,
pagine: 72 - 79
SICI:
0894-1491(200107)35:1<72:IROADA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE PRODUCTION; COLONY-STIMULATING FACTOR; AMYLOID-BETA-PEPTIDE; NF-KAPPA-B; COMPLEMENT PROTEINS; TRANSCRIPTION FACTORS; SYNTHASE EXPRESSION; NEURONAL EXPRESSION; SENILE PLAQUES; IN-VITRO;
Keywords:
glia; cell culture; Alzheimer's disease; cytokines; chemokines; complement; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Rogers, J Sun Hlth Res Inst, POB 1278, Sun City, AZ 85372 USA Sun Hlth ResInst POB 1278 Sun City AZ USA 85372 y, AZ 85372 USA
Citazione:
L.F. Lue et al., "Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro", GLIA, 35(1), 2001, pp. 72-79

Abstract

We have previously developed and characterized isolated microglia and astrocyte cultures from rapid (<4 h) brain autopsies of Alzheimer's disease (AD) and nondemented elderly control (ND) patients. In the present study, we evaluate the inflammatory repertoire of AD and ND microglia cultured from white matter (corpus callosum) and gray matter (superior frontal gyrus) with respect to three major proinflammatory cytokines, three chemokines, a classical pathway complement component, a scavenger cell growth factor, and a reactive nitrogen intermediate. Significant, dose-dependent increases in the production of pro-interleukin-1<beta> (pro-IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory peptide-1 alpha (MIP-1 alpha), IL-8, and macrophage colony-stimulating factor (M-CSF) were observed after exposureto pre-aggregated amyloid beta peptide (1-42) (A beta1-42). Across constitutive and A beta -stimulated conditions, secretion of complement component C1q, a reactive nitrogen intermediate, and M-CSF was significantly higher in AD compared with ND microglia. Taken together with previous in situ hybridization findings, these results demonstrate unequivocally that elderly human microglia provide a brain endogenous source for a wide range of inflammatory mediators. GLIA 35:72-79, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:28:13