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Titolo:
Plasma insulin-like growth factor I levels in the elderly: Relation to plasma dehydroepiandrosterone sulfate levels, nutritional status, health and mortality
Autore:
Raynaud-Simon, A; Lafont, S; Berr, C; Dartigues, JF; Baulieu, EE; Le Bouc, Y;
Indirizzi:
Hop Charles Foix, Unite Med Nutr Geriatr, AP HP, F-94205 Ivry, France Hop Charles Foix Ivry France F-94205 eriatr, AP HP, F-94205 Ivry, France Hop Trousseau, Lab Explorat Fonctionnelles Endocriniennes, Paris, France Hop Trousseau Paris France Fonctionnelles Endocriniennes, Paris, France Hop St Antoine, F-75571 Paris, France Hop St Antoine Paris France F-75571 op St Antoine, F-75571 Paris, France Univ Bordeaux 2, INSERM U330, Bordeaux, France Univ Bordeaux 2 Bordeaux France rdeaux 2, INSERM U330, Bordeaux, France Hop La Pitie Salpetriere, INSERM U360, Paris, France Hop La Pitie Salpetriere Paris France riere, INSERM U360, Paris, France Hop Bicetre, INSERm U488, Le Kremlin Bicetre, France Hop Bicetre Le Kremlin Bicetre France U488, Le Kremlin Bicetre, France
Titolo Testata:
GERONTOLOGY
fascicolo: 4, volume: 47, anno: 2001,
pagine: 198 - 206
SICI:
0304-324X(200107/08)47:4<198:PIGFIL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-DISEASE; COGNITIVE FUNCTION; BINDING PROTEIN-3; HORMONE SECRETION; SOMATOMEDIN-C; OLDER MEN; NHANES-I; IGF-I; CANCER; WOMEN;
Keywords:
insulin-like growth factor I, aging dehydroepiandrosterone sulfate; nutrition; mortality; cognition; depression; functional disability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Raynaud-Simon, A Hop Charles Foix, Unite Med Nutr Geriatr, AP HP, F-94205 Ivry, France Hop Charles Foix Ivry France F-94205 94205 Ivry, France
Citazione:
A. Raynaud-Simon et al., "Plasma insulin-like growth factor I levels in the elderly: Relation to plasma dehydroepiandrosterone sulfate levels, nutritional status, health and mortality", GERONTOLOGY, 47(4), 2001, pp. 198-206

Abstract

Background: Insulin-like growth factor I (IGF-I) has beneficial metabolic effects. Because plasma IGF-I levels have been reported to be enhanced by dehydroepiandrosterone (DHEA) administration, it has been suggested that theIGF-I may be implicated in some of the reported associations between low DHEA sulfate (DHEAS) levels and impaired health measures in elderly subjects. The nutritional status, which also regulates plasma IGF-I levels, is alsoan important determinant of health outcome. Objective:We sought to investigate the associations between plasma IGF-I revels and plasma DHEAS levels, nutritional status, health, and mortality in the elderly. Methods: In 256 community-dwelling subjects aged 65-101 years, enrolled in the Paquid study,a health questionnaire was used to a certain their functional disabilities, any history of medical disorders, self-perceived health, depressive symptoms, and their cognitive function. Biological measurements included levels of plasma IGF-I, albumin, transthyretin, and DHEAS. Mortality data were available for 6 years following blood sampling. Results: In this elderly population with no impairment in nutritional status, the plasma IGF-I levels decreased significantly with age (p = 0.02). The plasma IGF-I levels correlated positively with those of transthyretin (p = 0.0001). IGF-I also correlated with DHEAS (p = 0.04), but the correlation did not remain significant after adjustment for age. As opposed to SDHEA, the plasma IGF-I revels did notcorrelate with the results from the hearth questionnaire. The baseline IGF-I values in the highest tertile were associated with a higher risk of short-term mortality than those in the lowest tertile (RR = 8.4 at 2 years, p =0.007). Conclusions: Our results suggest that IGF-I is not connected with the association between low plasma DHEAS levels and the impaired results from the health questionnaire. The relationship between plasma IGF-I highest levels and mortality should be further explored. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:56:52