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Titolo:
Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis
Autore:
Yousef, GM; Diamandis, M; Jung, K; Diamandis, EP;
Indirizzi:
Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada Mt SinaiHosp Toronto ON Canada M5G 1X5 Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Lab Med & Pathol, Toronto, ON M5G 1L5, Canada Univ Toronto Toronto ON Canada M5G 1L5 athol, Toronto, ON M5G 1L5, Canada Humboldt Univ, Univ Hosp, Charite, Dept Urol, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 Dept Urol, D-10098 Berlin, Germany
Titolo Testata:
GENOMICS
fascicolo: 3, volume: 74, anno: 2001,
pagine: 385 - 395
SICI:
0888-7543(20010615)74:3<385:MCOANH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTATE-SPECIFIC ANTIGEN; KALLIKREIN-LIKE GENE; TESTICULAR CANCER; CHROMOSOME 19Q13.3-Q13.4; SEQUENCE; PROTEIN; IDENTIFICATION; TYPE-5; FAMILY; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Diamandis, EP Mt Sinai Hosp, Dept Pathol & Lab Med, 600 Univ Ave, Toronto,ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave Toronto ON Canada M5G 1X5 Canada
Citazione:
G.M. Yousef et al., "Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis", GENOMICS, 74(3), 2001, pp. 385-395

Abstract

Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. Prostatic acid phosphatase has served as a tumor marker for metastatic prostate cancer for many years. We have cloned a new human acid phosphatase gene (named testicular acid phosphatase, ACPT), which is expressed mainly in testis and to a lower extent in the prostate, trachea, and other tissues. This gene maps to chromosome 19q13.4, in an area that harbors many cancer-related genes. The testicular acid phosphatase gene is composed of 11 exons, and the protein is predicted to have a luminal domain, a transmembrane domain, and a cytoplasmic domain. The N-terminal end of the protein encodes a signal peptide. The protein has approximately 50% homology with both the prostatic and the lysosomal acid phosphatases, and the position of the cysteine residues, the N-glycosylation sites, and the histidine catalytic site are conserved among the three proteins. The testicular acid phosphatase gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line LNCaP. Our preliminary results indicate that this gene exhibits a lower level of expression in testicular cancer tissues than in their normal counterparts. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:05:24