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Titolo:
Genetic analysis of a new mouse model for non-insulin-dependent diabetes
Autore:
Kim, JH; Sen, S; Avery, CS; Simpson, E; Chandler, P; Nishina, PM; Churchill, GA; Naggert, JK;
Indirizzi:
Jackson Lab, Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor ME USA 04609Jackson Lab, Bar Harbor, ME 04609 USA Hammersmith Hosp, ICSM, MRC Clin Sci Ctr, Transplantat Biol Grp, London W12 0NN, England Hammersmith Hosp London England W12 0NN iol Grp, London W12 0NN, England Med Coll Georgia, Inst Mol Med & Genet, Dept Mol Immunol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Mol Immunol, Augusta, GA 30912 USA
Titolo Testata:
GENOMICS
fascicolo: 3, volume: 74, anno: 2001,
pagine: 273 - 286
SICI:
0888-7543(20010615)74:3<273:GAOANM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED GLUCOSE-TOLERANCE; OBESITY QTLS; GK RAT; MELLITUS; LOCI; SUSCEPTIBILITY; PREVALENCE; NIDDM; TRAIT; MICE;
Keywords:
mice; NIDDM; hyperglycemia; genetics; QTL; gene-gene interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Naggert, JK Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA Jackson Lab600 Main St Bar Harbor ME USA 04609 , ME 04609 USA
Citazione:
J.H. Kim et al., "Genetic analysis of a new mouse model for non-insulin-dependent diabetes", GENOMICS, 74(3), 2001, pp. 273-286

Abstract

The TallyHo (TH) mouse strain is a newly established model for non-insulin-dependent diabetes mellitus (NIDDM). TH mice show obesity, hyperinsulinemia, hyperlipidemia, and male-limited hyperglycemia. A genetic dissection of the diabetes syndrome has been carried out using male backcross 1 progeny obtained from crosses between (C57BL/6J x TH)F1 and TH mice or (CAST/Ei x TH)F1 and TH mice. A genome-wide scan reveals three quantitative trait loci (QTLs), Tanidd1-3 (TH-associated NIDDM) linked to hyperglycemia. The major QTL (common in both crosses), Tanidd1, maps to chromosome (Chr) 19. Additionally, gene-gene interactions contributing to hyperglycemia have been observed between Tanidd1 and a locus on Chr 18 as well as between Tanidd2 and a locus on Chr 16, The overt hyperglycemia in TH mice is, therefore, likely due to a mutation in a major diabetes susceptibility locus on Chr 19, which interacts with additional genes to lead to an observable phenotype. (C) 2001Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:06:49