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Titolo:
Linkage disequilibrium between microsatellite markers extends beyond 1 cM on chromosome 20 in Finns
Autore:
Mohlke, KL; Lange, EM; Valle, TT; Ghosh, S; Magnuson, VL; Silander, K; Watanabe, RM; Chines, PS; Bergman, RN; Tuomilehto, A; Collins, FS; Boehnke, M;
Indirizzi:
Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Biostat, Ann Arbor, MI 48109 USA NHGRI, Genet & Mol Biol Branch, Bethesda, MD 20892 USA NHGRI Bethesda MD USA 20892 net & Mol Biol Branch, Bethesda, MD 20892 USA Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet & Genet Epidemiol Unit, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Epidemiol Unit, Helsinki, Finland Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033USA Univ So Calif Los Angeles CA USA 90033 Biophys, Los Angeles, CA 90033USA Univ Helsinki, Dept Publ Hlth, Helsinki, Finland Univ Helsinki Helsinki Finland sinki, Dept Publ Hlth, Helsinki, Finland
Titolo Testata:
GENOME RESEARCH
fascicolo: 7, volume: 11, anno: 2001,
pagine: 1221 - 1226
SICI:
1088-9051(200107)11:7<1221:LDBMME>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; ISOLATED POPULATIONS; GENETICS FUSION; MAPPING GENES; FINLAND; GENOME; CONCORDANCE; REGIONS; TWINS; SCAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Boehnke, M Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109USA Univ Michigan Ann Arbor MI USA 48109 , Ann Arbor, MI 48109 USA
Citazione:
K.L. Mohlke et al., "Linkage disequilibrium between microsatellite markers extends beyond 1 cM on chromosome 20 in Finns", GENOME RES, 11(7), 2001, pp. 1221-1226

Abstract

Linkage disequilibrium (LD) is a proven tool for evaluating population structure and localizing genes for monogenic disorders. LD-based methods may also help localize genes for complex traits. We evaluated marker-marker LD using 43 microsatellite markers spanning chromosome 20 with an average density of 2.3 cM. We studied 837 individuals affected with type 2 diabetes and 386 mostly unaffected spouse controls. A test of homogeneity between the affected individuals and their spouses showed no difference, allowing the 1223 individuals to be analyzed together. Significant (P < 0.01) LD was observed using a likelihood ratio test in all (11/11) marker pairs within 1 cM, 78% (25/32) of pairs 1-3 cM apart, and 39% (7/18) of pairs 3-4 cM apart, butfor only 12 of 842 pairs more than 4 cM apart. We used the human genome project working draft sequence to estimate kilobase (kb) intermarker distances, acid observed highly significant LD (P < 10(-10)) for all six marker pairs up to 350 kb apart, although the correlation of LD with cM is slightly better than the correlation with megabases. These data suggest that microsatellites present at 1-cM density are sufficient to observe marker-marker LD in the Finnish population.

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Documento generato il 05/04/20 alle ore 09:46:54