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Titolo:
Temporal gene regulation during HIV-1 infection of human CD4(+) T cells
Autore:
Corbeil, A; Sheeter, D; Genini, D; Rought, S; Leoni, L; Du, PY; Ferguson, M; Masys, DR; Welsh, JB; Fink, JL; Sasik, R; Huang, D; Drenkow, J; Richman, DD; Gingeras, T;
Indirizzi:
Univ Calif San Diego, Dept Med, La Jolla, CA 92023 USA Univ Calif San Diego La Jolla CA USA 92023 pt Med, La Jolla, CA 92023 USA Univ Calif San Diego, Dept Pathol, La Jolla, CA 92023 USA Univ Calif San Diego La Jolla CA USA 92023 Pathol, La Jolla, CA 92023 USA Univ Calif San Diego, Dept Phys, La Jolla, CA 92023 USA Univ Calif San Diego La Jolla CA USA 92023 t Phys, La Jolla, CA 92023 USA Vet Adm Med Ctr, San Diego, CA 92161 USA Vet Adm Med Ctr San Diego CA USA92161 m Med Ctr, San Diego, CA 92161 USA Vet Med Res Fdn, San Diego, CA 92161 USA Vet Med Res Fdn San Diego CA USA92161 d Res Fdn, San Diego, CA 92161 USA San Diego Supercomp Ctr, La Jolla, CA 92093 USA San Diego Supercomp Ctr La Jolla CA USA 92093 Ctr, La Jolla, CA 92093 USA Affymetrix, Santa Clara, CA USA Affymetrix Santa Clara CA USAAffymetrix, Santa Clara, CA USA
Titolo Testata:
GENOME RESEARCH
fascicolo: 7, volume: 11, anno: 2001,
pagine: 1198 - 1204
SICI:
1088-9051(200107)11:7<1198:TGRDHI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53-REGULATED PROTEIN GADD45; TUMOR-SUPPRESSOR P53; NUCLEAR FACTOR-I; EXPRESSION PATTERNS; APOPTOSIS; IDENTIFICATION; MITOCHONDRIA; LYMPHOCYTES; ACTIVATION; INTERACTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Corbeil, A Univ Calif San Diego, Dept Med, La Jolla, CA 92023 USA Univ Calif San Diego La Jolla CA USA 92023 Jolla, CA 92023 USA
Citazione:
A. Corbeil et al., "Temporal gene regulation during HIV-1 infection of human CD4(+) T cells", GENOME RES, 11(7), 2001, pp. 1198-1204

Abstract

CD4(+) T-cell depletion is a characteristic of human immunodeficiency virus type 1 (HIV-1) infection. In this study, modulation of mRNA expression of6800 genes was monitored simultaneously at eight time points in a CD4(+) T-cell line (CEM-GFP) during HIV infection. The responses to infection included: (1) >30% decrease at 72 h after infection in overall host-cell production of monitored mRNA synthesis, with the replacement of host-cell mRNA by viral mRNA, (2) suppression of the expression of selected mitochondrial andDNA repair gene transcripts, (3) increased expression of the proapoptotic gene and its gene p53-induced product Bax, and (4) activation of caspases 2, 3, and 9. The intense HIV-1 transcription resulted in the repression of much cellular RNA expression and was associated with the induction of apoptosis of infected cells but not bystander cells. This choreographed host generesponse indicated that the subversion of the cell transcriptional machinery for the purpose of HIV-1 replication is akin to genotoxic stress and represents a major factor leading to HIV-induced apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:20:35