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Titolo:
Safety of a GM-CSF adjuvant-plasmid DNA malaria vaccine
Autore:
Parker, SE; Monteith, D; Horton, H; Hof, R; Hernandez, P; Vilalta, A; Hartikka, J; Hobart, P; Bentley, CE; Chang, A; Hedstrom, R; Rogers, WO; Kumar, S; Hoffman, SL; Norman, JA;
Indirizzi:
Vical Inc, San Diego, CA 92121 USA Vical Inc San Diego CA USA 92121Vical Inc, San Diego, CA 92121 USA Sierra Biomed, San Diego, CA USA Sierra Biomed San Diego CA USASierra Biomed, San Diego, CA USA BioReliance Inc, Rockville, MD USA BioReliance Inc Rockville MD USABioReliance Inc, Rockville, MD USA USN, Med Ctr, Malaria Program, Bethesda, MD 20814 USA USN Bethesda MD USA20814 ed Ctr, Malaria Program, Bethesda, MD 20814 USA
Titolo Testata:
GENE THERAPY
fascicolo: 13, volume: 8, anno: 2001,
pagine: 1011 - 1023
SICI:
0969-7128(200107)8:13<1011:SOAGAD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; CYTOTOXIC T-LYMPHOCYTES; IN-VIVO TRANSFECTION; IMMUNE-RESPONSES; PROTECTIVE IMMUNITY; ANTIGEN PRESENTATION; EXPRESSION VECTOR; VIRUS-INFECTION; DENDRITIC CELLS; GENE-THERAPY;
Keywords:
plasmid DNA vaccine; GM-CSF; malaria; safety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Parker, SE Vical Inc, 9373 Towne Ctr Dr,Suite 100, San Diego, CA 92121 USAVical Inc 9373 Towne Ctr Dr,Suite 100 San Diego CA USA 92121 SA
Citazione:
S.E. Parker et al., "Safety of a GM-CSF adjuvant-plasmid DNA malaria vaccine", GENE THER, 8(13), 2001, pp. 1011-1023

Abstract

MuStDO 5 is a multivalent plasmid DNA vaccine for malaria comprised of five plasmid DNAs encoding five proteins from Plasmodium falciparum and one plasmid DNA encoding human GM-CSF. To evaluate the safety of MuStDO 5, a series of pre-clinical studies were conducted in mice and rabbits. In pharmacology studies in mice, GM-CSF could not be detected in the serum following either intramuscular or a combined intramuscular/intradermal administration of the vaccine, but was readily detected in the muscle following intramuscular administration. In a tissue distribution study in mice, MuStDO 5 plasmidDNA was detected by PCR initially in highly vascularized tissues, while atlater time-points the plasmid DNA was detected primarily at the site(s) ofinjection. In GLP safety studies in mice and rabbits, repeated intramuscular/intradermal administration of the MuStDO 5 vaccine was found to be safe and well tolerated without any evidence of autoimmune pathology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:50:29