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Titolo:
Genes modulated by histone acetylation as new effecters of butyrate activity
Autore:
Della Ragione, F; Criniti, V; Della Pietra, V; Borriello, A; Oliva, A; Indaco, S; Yamamoto, T; Zappia, V;
Indirizzi:
Univ Naples, Sch Med, Dept Biochem & Biophys F Cedranglo, I-80138 Naples, Italy Univ Naples Naples Italy I-80138 phys F Cedranglo, I-80138 Naples, Italy Univ Tokyo, Inst Med Sci, Dept Oncol, Minato Ku, Tokyo 1088639, Japan UnivTokyo Tokyo Japan 1088639 pt Oncol, Minato Ku, Tokyo 1088639, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 499, anno: 2001,
pagine: 199 - 204
SICI:
0014-5793(20010622)499:3<199:GMBHAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTIONAL REGULATORY COMPLEX; COLON-CANCER CELLS; LARGE-BOWEL CANCER; CHAIN FATTY-ACIDS; SODIUM-BUTYRATE; TRICHOSTATIN-A; DIETARY FIBER; EXPRESSION; DIFFERENTIATION; PROTEIN;
Keywords:
butyrate; trichostatin A; histone hyperacetylation; histone deacetylase; GATA-2; tob-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Della Ragione, F Univ Naples, Sch Med, Dept Biochem & Biophys F Cedranglo,Via Costantinopoli 16, I-80138 Naples, Italy Univ Naples Via Costantinopoli 16 Naples Italy I-80138 y
Citazione:
F. Della Ragione et al., "Genes modulated by histone acetylation as new effecters of butyrate activity", FEBS LETTER, 499(3), 2001, pp. 199-204

Abstract

A wealth of evidence correlates the chemopreventive activity of a fiber-rich diet with the production of butyrate, In order to identify tbe genes transcriptionally modulated by the molecule, we analyzed the expression profile of butyrate-treated colon cancer cells by means of cDNA expression arrays, Moreover, the effect of trichostatin A, a specific histone deacetylase inhibitor, was studied, A superimposable group of 23 genes out of 588 investigated is modulated by both butyrate and trichostatin A, Among them, a majortarget was tob-1, a gene involved in the control of cell cycle. toh-l is also upregulated by butyrate in a neuroblastoma-derived cell line, and its overexpression in the colon cells caused growth arrest. Our findings represent an extensive analysis of genes modulated by butyrate and identify completely new effecters of its biological activities. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:19:01