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Titolo:
Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis
Autore:
Claud, EC; Walker, WA;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med,Combined Program Pediat Gastroenterol & N, Dev Gastroenterol Lab, Boston, MA USA Harvard Univ Boston MA USA ol & N, Dev Gastroenterol Lab, Boston, MA USA
Titolo Testata:
FASEB JOURNAL
fascicolo: 8, volume: 15, anno: 2001,
pagine: 1398 - 1403
SICI:
0892-6638(200106)15:8<1398:HICOTP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; RAT SMALL-INTESTINE; ISCHEMIC BOWEL NECROSIS; BREAST-FED INFANTS; NF-KAPPA-B; BACTERIAL-COLONIZATION; EPITHELIAL-CELLS; HUMAN-MILK; SALMONELLA-TYPHIMURIUM; FACTOR ACETYLHYDROLASE;
Keywords:
necrotizing enterocolitis; prematurity; intestinal inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, WA Massachusetts Gen Hosp, Dev Gastroenterol Lab, 149 13th St, Charlestown, MA 02129 USA Massachusetts Gen Hosp 149 13th St Charlestown MA USA 02129 USA
Citazione:
E.C. Claud e W.A. Walker, "Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis", FASEB J, 15(8), 2001, pp. 1398-1403

Abstract

Neonatal necrotizing enterocolitis (NEC) is a major cause of morbidity in preterm infants. We hypothesize that the intestinal injury in this disease is a consequence of synergy among three of the major risk factors for NEC: prematurity, enteral feeding, and bacterial colonization. Together these factors result in an exaggerated inflammatory response, leading to ischemic bowel necrosis. Human milk may decrease the incidence of NEC by decreasing pathogenic bacterial colonization, promoting growth of nonpathogenic flora, promoting maturation of the intestinal barrier, and ameliorating the proinflammatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:46:29