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Titolo:
The ventral hippocampus and fear conditioning in rats - Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol
Autore:
Bast, T; Zhang, WN; Feldon, J;
Indirizzi:
Swiss Fed Inst Technol, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 139, anno: 2001,
pagine: 39 - 52
SICI:
0014-4819(200107)139:1<39:TVHAFC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PASSIVE-AVOIDANCE RESPONSE; METHYL-D-ASPARTATE; NUCLEUS-ACCUMBENS; CONTEXTUAL FEAR; FUNCTIONAL INACTIVATION; BASOLATERAL AMYGDALA; LOCOMOTOR-ACTIVITY; LATENT INHIBITION; DOPAMINE RELEASE; MEMORY CONSOLIDATION;
Keywords:
classical fear conditioning; locomotor activity; muscimol; tetrodotoxin; ventral hippocampus; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Neurobiol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
T. Bast et al., "The ventral hippocampus and fear conditioning in rats - Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol", EXP BRAIN R, 139(1), 2001, pp. 39-52

Abstract

Studies on the involvement of the rat hippocampus in classical fear conditioning have focused mainly on the dorsal hippocampus and conditioning to a context. However, the ventral hippocampus has intimate connections with theamygdala and the nucleus accumbens, which are involved in classical fear conditioning to explicit and contextual cues. Consistently, a few recent lesion studies have indicated a role for the ventral hippocampus in classical fear conditioning to explicit and contextual cues. The present study examined whether neuronal activity within the ventral hippocampus is important for the formation of fear memory to explicit and contextual cues by classicalfear conditioning. Tetrodotoxin (TTX; 10 ng/side), which completely blocksneuronal activity, or muscimol (1 mug/side), which increases GABA(A) receptor-mediated inhibition, were bilaterally infused into the ventral hippocampus of Wistar rats before the conditioning session of a classical fear-conditioning experiment. Conditioning to a tone and the context were assessed using freezing as a measure of conditioned fear. TTX blocked fear conditioning to both tone and context. Muscimol only blocked fear conditioning to thecontext. The data of the present study indicate that activity of neurons in the ventral hippocampus is necessary for the formation of fear memory to both explicit and contextual cues and that neurons in the ventral hippocampus that bear the GABA, receptor are important for the formation of fear conditioning to a context. In addition, both bilateral muscimol (0.5 mug/side and 1 mug/side) and TTX (5 ng/side and 10 ng/side) infusion into the ventral hippocampus dose-dependently decreased locomotor activity in an open-field experiment.

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Documento generato il 19/01/20 alle ore 00:36:11