Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Modern concepts for the prediction of type 1 diabetes
Autore:
Seissler, J; Hatziagelaki, E; Scherbaum, WA;
Indirizzi:
Univ Dusseldorf, German Diabet Res Inst, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Athens, Evangelismos Hosp, Res Inst, Dept Internal Med 2, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 ternal Med 2, GR-10679 Athens, Greece Univ Athens, Evangelismos Hosp, Ctr Diabet, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 , Ctr Diabet, GR-10679 Athens, Greece
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
, volume: 109, anno: 2001, supplemento:, 2
pagine: S304 - S316
SICI:
0947-7349(2001)109:<S304:MCFTPO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET-CELL ANTIBODIES; GLUTAMIC-ACID DECARBOXYLASE; PROTEIN-TYROSINE-PHOSPHATASE; INSULIN AUTOANTIBODIES; POSITIVE RELATIVES; GENERAL-POPULATION; RISK ASSESSMENT; T-CELLS; MELLITUS; IDDM;
Keywords:
type 1 diabetes; autoantibodies; prediction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Seissler, J Univ Dusseldorf, German Diabet Res Inst, Hennekamp 65, D-40225Dusseldorf,Germany Univ Dusseldorf Hennekamp 65 Dusseldorf Germany D-40225 rmany
Citazione:
J. Seissler et al., "Modern concepts for the prediction of type 1 diabetes", EXP CL E D, 109, 2001, pp. S304-S316

Abstract

Type 1 diabetes results from the destruction of the insulin-producing betacells of the pancreas. The disease process is thought to be initiated by acomplex interaction between genetic and environmental factors leading to acellular and humoral autoimmune response against beta cell specific components. Over the past decade there has been important progress in identification of several diabetes specific autoantigens. The availability of recombinant antigens, most notably the enzyme glutamic acid decarboxylase (GAD) andthe tyrosine phosphatase-like molecule IA-2, made it possible to develop simple, sensitive and specific radioimmunoassays for the detection of autoantibodies on a large scale. It has been shown that the combination of GAD antibodies (GADA) and IA-2 antibodies (IA-2-A) with insulin autoantibodies (IAA) can replace the conventional ICA test. This considerably facilitates screening programmes. prospective studies in subjects with and without familyhistory of type 1 diabetes conclusively demonstrate that the risk for type1 diabetes is strongly correlated with the number of positive antibodies, The 5-10-years risk for type I diabetes varies from 0-1% in individuals with only one positive antibodies to 62-100% in subjects who were positive forthree or more antibodies. Despite the identification of novel genetic markers associated with type 1 diabetes, the major histocompatibility complex, namely HLA-DQ alleles, still represents the strongest genetic risk factor, The analysis of HLA-DQ alleles may be important to discriminate between subjects at high or intermediate risk from antibody positive individuals carrying protective haplotypes. Assessment oi the metabolic state using the first phase insulin response to intravenous glucose may provide additional information to pre diet rapid progression to diabetes. Screening for multiple antibodies is the most specific and sensitive strategy for identifying subject at risk for type I diabetes.. Second-line genotyping or analysis of the first phase insulin response can serve as useful tool to improve the prediction of type 1 diabetes, The value of additional markers such as isotype specific autoantibodies or T-helper cells subsets measured by ELISPOT assays or FAGS remains to be shown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:31:12