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Titolo:
Metformin, the rebirth of a biguanide: mechanism of action and place in the prevention and treatment of insulin resistance
Autore:
Mehnert, H;
Indirizzi:
Stadt Akad Lehrkrankenhaus Munchen Schwabing, Inst Diabet Forsch, Munich, Germany Stadt Akad Lehrkrankenhaus Munchen Schwabing Munich Germany ch, Germany
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
, volume: 109, anno: 2001, supplemento:, 2
pagine: S259 - S264
SICI:
0947-7349(2001)109:<S259:MTROAB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; LIPID-METABOLISM; HEALTHY-SUBJECTS; SKELETAL-MUSCLE; LACTIC-ACIDOSIS; GLUCOSE; THERAPY; NIDDM; SULFONYLUREAS; DISEASE;
Keywords:
metformin; biguanides; diabetes mellitus; insulin resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Mehnert, H Stadt Krankenhaus Munchen Schwabing, Inst Diabet Forsch, KolnerPl 1, D-80804 Munich, Germany Stadt Krankenhaus Munchen Schwabing Kolner Pl 1 Munich Germany D-80804
Citazione:
H. Mehnert, "Metformin, the rebirth of a biguanide: mechanism of action and place in the prevention and treatment of insulin resistance", EXP CL E D, 109, 2001, pp. S259-S264

Abstract

Metformin should be regarded as a first-choice therapy of type 2 diabetes,showing an especially good efficacy in obese patients with hyperinsulinaemia. Reduction of blood glucose without hyperinsulinaemia and without hypoglycaemia, favourable influence on the lipid profile and inhibition of coagulation factors lead to an antidiabetic and antiatherogenic effect. Not only are these characteristics relevant to judging the value of the drug, but also the strict observation of contraindications is needed to avoid the dangerous complication of lactic acidosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:00:34