Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Myocardial injury and systemic fibrinolysis in patients undergoing repair of ruptured abdominal aortic aneurysm: a preliminary report
Autore:
Haggart, PC; Adam, DJ; Ludman, PF; Ludman, CA; Bradbury, AW;
Indirizzi:
Univ Birmingham, Dept Vasc Surg, Birmingham Heartlands & Solihull NHS Trust, Birmingham B9 5SS, W Midlands, England Univ Birmingham Birmingham W Midlands England B9 5SS W Midlands, England Birmingham Heartlands & Solihull NHS Trust, Dept Cardiol, Birmingham, W Midlands, England Birmingham Heartlands & Solihull NHS Trust Birmingham W Midlands England Univ Edinburgh, Dept Clin & Surg Sci, Vasc Surg Unit, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland burgh, Midlothian, Scotland Royal Infirm Edinburgh, Dept Haematol, Edinburgh, Midlothian, Scotland Royal Infirm Edinburgh Edinburgh Midlothian Scotland idlothian, Scotland
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 529 - 534
SICI:
1078-5884(200106)21:6<529:MIASFI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TROPONIN-I; MAJOR NONCARDIAC SURGERY; ACUTE CORONARY SYNDROMES; VASCULAR-SURGERY; PROGNOSTIC VALUE; ANGINA-PECTORIS; INFARCTION; DIAGNOSIS; MORBIDITY; MORTALITY;
Keywords:
aortic allaneurysm; post-operative myocardial infarction; troponin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Haggart, PC Univ Birmingham, Dept Vasc Surg, Birmingham Heartlands & Solihull NHS Trust, Lincoln Bldg Res Inst, Birmingham B9 5SS, W Midlands, England Univ Birmingham Lincoln Bldg Res Inst Birmingham W Midlands England B9 5SS
Citazione:
P.C. Haggart et al., "Myocardial injury and systemic fibrinolysis in patients undergoing repair of ruptured abdominal aortic aneurysm: a preliminary report", EUR J VAS E, 21(6), 2001, pp. 529-534

Abstract

Background: ruptured abdominal aortic aneurysm (AAA) is associated with inhibition of systemic fibrinolysis. Hypofibrinolysis is a risk-factor for ischaemic myocardial injury, one of the commonest complications of ruptured AAA repair. Cardiac troponin I (cTnI) is one of the most sensitive and specific marker of myocardial injury currently available. Objective: to examine, for the first time, the relationship between fibrinolytic activity and myocardial injury in patients operated for ruptured AAA. Methods: twenty patients (18 men and 2 women of median age 74, range 65-86years) undergoing repair of ruptured AAA were prospectively studied. Plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) activity were measured pre-operatively, immediately before and five minutes following aortic clamp release. Serum cTnI was measured pre-operatively, 6 and 24 h following clamp release. Results: cTnI was detectable at one or more sample points in 13 (65%) patients, and in 7 out of 8 patients who suffered major cardiac complications. There was a significant negative correlation between pre-operative t-PA activity and cTnI before operation (r = -0.55, p = 0.01) and 6 h (r = -0.51, p= 0.02) after clamp release. There was a significant positive correlation between pre-operative PAI activity and cTnI before operation (r = +0.50, p = 0.03), 6 h (r = +0.47, p = 0.04) and 24 h (r = +0.50, p = 0.03) after clamp release. There was no correlation between pre- and intra-operative hypotension or blood transfusion requirement and cTnI release. Conclusions: hypofibrinolysis during ruptured AAA repair is associated with the development of peri-operative myocardial injury. The causal mechanisms underlying this state are not clear but treatment of this prothrombotic/hypofibrinolytic diathesis may help to limit myocardial cell necrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 06:35:02