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Titolo:
Immunophenotypic characterisation of carotid plaque: Increased amount of inflammatory cells as an independent predictor for ischaemic symptoms
Autore:
Schumacher, H; Kaiser, E; Schnabel, PA; Sykora, J; Eckstein, HH; Allenberg, JR;
Indirizzi:
Univ Heidelberg, Dept Vasc Surg, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Univ Heidelberg, Inst Pathol, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 494 - 501
SICI:
1078-5884(200106)21:6<494:ICOCPI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROTIC PLAQUES; ARTERY STENOSIS; MORPHOLOGY; ENDARTERECTOMY; RUPTURE; STROKE; EVENTS; RISK;
Keywords:
eversion endarterectomy; carotid plague; characterisation; immunochemistry; inflammation; stroke predictor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Schumacher, H Univ Heidelberg, Dept Vasc Surg, Kirschnerstr 1, D-69120 Heidelberg, Germany Univ Heidelberg Kirschnerstr 1 Heidelberg Germany D-69120y
Citazione:
H. Schumacher et al., "Immunophenotypic characterisation of carotid plaque: Increased amount of inflammatory cells as an independent predictor for ischaemic symptoms", EUR J VAS E, 21(6), 2001, pp. 494-501

Abstract

Objectives: to investigate the inflammatory response within intact carotidplaques from carotid eversion endarterectomy (CEE) to determine the relationship between immunohistological plaque morphology and ischaemic cerebrovascular symptoms. Materials and methods: intact CEE plaques from 71 patients with high-grade(> 70%) stenosis undergoing CEE (group I, symptomatic, n = 42; group II, asymptomatic, n = 29) and 12 normal postmortem arteries (control group) wereanalysed with specific antibodies to inflammatory cells (T-Lymphocytes (CD3, CD4), cytotoxic T-cells (CD8), B-lymphocytes (CD20), natural killer cells (CD57), macrophages (CD68)), endothelial adhesion molecules (ICAM-1 (CD54), P-selectin (CD62P), E-selectin (CD62E), VCAM-1 (CD106) and T-lymphocyte co-stimulatory molecule (CD40)) and procoagulatory modulators (thrombomodulin (CD141), tissue factor (CD142)). Both groups were matched for gender, age, risk factors, degree of carotid artery stenosis. Plaques were measured using a semiquantitative score system in a blinded fashion by two observers. Statistical analysis of the group differences were performed by using the Kruskal-Wallis test and the Multitest Procedure with Permutation-Testing. Significance was taken as a p <0.05. Results: there were significantly more inflammatory cells, an overexpression of P-selectin and the procoagulatory markers thrombomodulin and tissue factor in symptomatic compared to both asymptomatic plaques and the ones of the control group. In both groups there was no significance for ICAM-1, VCAM-1, macrophages and co-stimulatory molecule CD40. There was also no significance for any factor between the asymptomatic and the control group. However, the differences between the symptomatic and the asymptomatic group werehighly significant for all factors. Conclusion; these data suggest that structural changes and inflammatory damage within the individual plaque seems to be a critical step in promoting plaque rupture with embolic sequelae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:42:53