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Titolo:
Expression of thrombopoietin by umbilical vein endothelial cells
Autore:
El Andaloussi, A; Duchez, P; Reiffers, J; Ripoche, J; Grosset, C;
Indirizzi:
Univ Bordeaux 2, UMR 5540, Lab Greffe Moelle, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 Moelle, F-33076 Bordeaux, France
Titolo Testata:
EUROPEAN CYTOKINE NETWORK
fascicolo: 2, volume: 12, anno: 2001,
pagine: 268 - 273
SICI:
1148-5493(200104/06)12:2<268:EOTBUV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MEGAKARYOCYTE GROWTH; MARROW STROMAL CELLS; C-MPL LIGAND; MESSENGER-RNA EXPRESSION; HEMATOPOIETIC STEM-CELLS; EARLY ACTING CYTOKINES; IN-SITU HYBRIDIZATION; BONE-MARROW; PROGENITOR CELLS; PLATELET PRODUCTION;
Keywords:
thrombopoietin; umbilical vein endothelial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: El Andaloussi, A Inst Pasteur Maroc, Lab Cytogenet, BP 120,1 Pl Aboukalem Ezzahraoui, Casablanca, Morocco Inst Pasteur Maroc BP 120,1 Pl Aboukalem Ezzahraoui Casablanca Morocco
Citazione:
A. El Andaloussi et al., "Expression of thrombopoietin by umbilical vein endothelial cells", EUR CYTOKIN, 12(2), 2001, pp. 268-273

Abstract

Current data suggest that the primary source of thrombopoietin (TPO) is the liver. Extra-hepatic sites for TPO production have been demonstrated essentially through the study of the expression of TPO mRNA. In this work, we report that TPO is expressed at low levels by endothelial cells (EC) derivedfrom the umbilical vein (HUVEC). Both TPO mRNA and the protein are expressed and the protein is functional as assessed by biological assay. Expression of TPO by HUVEC may be useful to study the regulation of the production of this cytokine and to understand the apparent specific interactions between mature megakaryocytes and EC in the bone marrow.

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Documento generato il 05/04/20 alle ore 19:30:34