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Titolo:
DNA methylation in breast cancer
Autore:
Yang, X; Yan, L; Davidson, NE;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Oncol, Johns Hopkins Oncol Ctr,Breast Canc Program, Baltimore, MD 21231 USA Johns Hopkins Univ Baltimore MD USA 21231 rogram, Baltimore, MD 21231 USA
Titolo Testata:
ENDOCRINE-RELATED CANCER
fascicolo: 2, volume: 8, anno: 2001,
pagine: 115 - 127
SICI:
1351-0088(200106)8:2<115:DMIBC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE S-TRANSFERASES; RECEPTOR GENE-EXPRESSION; MAMMALIAN HISTONE DEACETYLASE; MAMMARY EPITHELIAL-CELLS; CPG ISLAND METHYLATION; EMBRYONIC STEM-CELLS; E-CADHERIN; ESTROGEN-RECEPTOR; PROMOTER HYPERMETHYLATION; METHYLTRANSFERASE GENE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Davidson, NE Johns Hopkins Univ, Sch Med, Dept Oncol, Johns Hopkins Oncol Ctr,Breast Canc Program, 1650 Orleans St,CRB416, Baltimore, MD 21231 USA Johns Hopkins Univ 1650 Orleans St,CRB416 Baltimore MD USA 21231
Citazione:
X. Yang et al., "DNA methylation in breast cancer", ENDOCR-R CA, 8(2), 2001, pp. 115-127

Abstract

Like all cancers, breast cancer is considered to result in part from the accumulation of multiple genetic alterations leading to oncogene overexpression and tumor suppressor loss. More recently, the role of epigenetic changeas a distinct and crucial mechanism to silence a variety of methylated tissue-specific and imprinted genes has emerged in many cancer types. This review will briefly discuss basic aspects of DNA methylation, recent advances in DNA methyltransferases, the role of altered chromatin organization and the concept of gene transcriptional regulation built on methylated CpGs, In particular, we discuss epigenetic regulation of certain critical tumor suppressor and growth regulatory genes implicated in breast cancer, and its relevance to breast cancer diagnosis, prognosis, progression and therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:22:50