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Titolo:
Fine-needle aspiration cytology of the breast: Invasive vs. in situ carcinoma
Autore:
McKee, GT; Tambouret, RH; Finkelstein, D;
Indirizzi:
Massachusetts Gen Hosp, Dept Cytopathol, Boston, MA 02493 USA Massachusetts Gen Hosp Boston MA USA 02493 topathol, Boston, MA 02493 USA
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 73 - 77
SICI:
8755-1039(200107)25:1<73:FACOTB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCTAL CARCINOMA; IN-SITU; MAMMOGRAPHIC FEATURES; INSITU; DIAGNOSIS; CANCER; MASSES;
Keywords:
fine-needle aspirates; breast; invasive; in situ; carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: McKee, GT Massachusetts Gen Hosp, Dept Cytopathol, WRN 2,55 Fruit St, Boston, MA 02493 USA Massachusetts Gen Hosp WRN 2,55 Fruit St Boston MA USA 02493 USA
Citazione:
G.T. McKee et al., "Fine-needle aspiration cytology of the breast: Invasive vs. in situ carcinoma", DIAGN CYTOP, 25(1), 2001, pp. 73-77

Abstract

The surgical management of invasive breast carcinoma differs from that of in situ disease. Invasive carcinoma necessitates axillary lymph node dissection, a procedure that has associated morbidity. We studied 80 cases (66 invasive, 14 in situ) of breast carcinoma that had a histological diagnosis and a preoperative fine-needle aspirate. All slides were reviewed, with 17 cytologic features assessed. We found that six of these features showed a statistically significant difference between the invasive and in situ cases. These were infiltration of fat or stroma by malignant cells (72% of invasive cases demonstrated this feature, but it was not present in any of the in situ cases, P = 0.0002), the presence of myoepithelial cells overlying clusters of tumor cells (seen in 86% of in situ tumors and 7% of invasive cases. P < 0.00001), calcification (present in 71% of in situ and 15% of the invasive group, P = 0.001), foamy macrophages (noted in 64% of in situ tumors and 16% of invasive carcinomas, P = 0.0007), intracytoplasmic vacuoles (seen in 50% of invasive cases and 21% of in situ lesions, P = 0.08), and tubules (present in 30% of invasive and 7% of in situ tumors, P = 0.10). We demonstrate that invasion can be suggested in fine-needle aspirates of carcinomas. provided that true infiltration of fibrofatty connective tissue by neoplastic cells is present. In situ disease has characteristic features, but the presence of invasion cannot be excluded, even in the presence of stromalor adipose tissue fragments without tumor infiltration. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:49:52