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Titolo:
Cytodiagnosis of nipple discharge: A study of 602 samples from 484 cases
Autore:
Das, DK; Al-Ayadhy, B; Ajrawi, MTG; Shaheen, AA; Sheikh, ZA; Malik, M; Pathan, SK; Ebrahim, B; Francis, IM; Satar, SA; Abdulla, MA; Luthra, UK; Junaid, TA;
Indirizzi:
Kuwait Univ, Fac Med, Dept Pathol, Safat 13110, Kuwait Kuwait Univ SafatKuwait 13110 Fac Med, Dept Pathol, Safat 13110, Kuwait
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 25 - 37
SICI:
8755-1039(200107)25:1<25:CONDAS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOLOGY; BREAST; GALACTOGRAPHY; ASPIRATION; MANAGEMENT; WOMEN;
Keywords:
nipple discharge; cytology; fine-needle aspiration; breast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Das, DK Kuwait Univ, Fac Med, Dept Pathol, POB 24923, Safat 13110, Kuwait Kuwait Univ POB 24923 Safat Kuwait 13110 923, Safat 13110, Kuwait
Citazione:
D.K. Das et al., "Cytodiagnosis of nipple discharge: A study of 602 samples from 484 cases", DIAGN CYTOP, 25(1), 2001, pp. 25-37

Abstract

To find out the gross and microscopic differentiating features between nipple discharges (ND) due to various breast lesions, smears of 602 ND samplesfrom 484 cases were reviewed by one of the investigators (D.K.D.). The reviewed cytodiagnoses were as follows: benign nipple discharge (59.1%), inflammatory ND (6.5%). ?papillary lesions (2.5%), papillary lesions (20.6%), papillary lesions with atypia (3.8%), duct cells with atypia (0.5%), suspicious for malignancy (0.5%), malignant ND (1.2%), and inadequate (5.6%). Following review, samples with epithelial abnormalities (?papillary lesions, papillary lesions with and without atypia, duct cells with atypia, suspicious for malignancy, and malignancy) increased from 16.6% to 30.4% of adequate samples (P < 0.0001). 37.9% unilateral ND samples showed epithelial abnormalities, as opposed to 18.9% of bilateral ND samples (P < 0.0001). Bloodstained ND showed epithelial abnormalities in 41.5% samples, as compared to 22.1% of ND with other specified gross characteristics (P <0.0001). The sampleswith epithelial abnormalities differed significantly from benign and inflammatory ND in respect of frequency of benign duct cells, duct cells with atypia, papillary clusters or with or without atypia, malignant cells, columnar cells, red blood cells, inflammatory cells, and background lipid vacuoles (P < 0 0.01 to < 0.0001). The ND samples with suspicious and malignant cytology, besides the presence of malignant cells (P < 0.0001), differed significantly from rest of the lesions in respect of foam cells (P < 0.0001), red blood cells (P <0.01), and inflammatory cells (P < 0.05). When compared with histopathological diagnosis in 20 cases, the benign or malignant nature of the lesion was correctly identified in ND in 80% cases. The ND cytologies in 7 histologically proved malignant cases were malignancy (3 cases), suspicious for malignancy (1 case), papillary lesion with atypia (1 case), papillary lesion (1 case), and benign ND (1 case). (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:04:44