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Titolo:
Cytokine therapeutics for asthma: An appraisal of current evidence and future prospects
Autore:
Alvarez, D; Wiley, RE; Jordana, M;
Indirizzi:
McMaster Univ, Ctr Gene Therapeut, Dept Pathol & Mol Med, Div Resp Dis & Allergy,Hlth Sci Ctr, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 tr, Hamilton, ON L8N 3Z5, Canada
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 11, volume: 7, anno: 2001,
pagine: 1059 - 1081
SICI:
1381-6128(200107)7:11<1059:CTFAAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1 RECEPTOR ANTAGONIST; NECROSIS-FACTOR-ALPHA; INDUCED AIRWAY HYPERRESPONSIVENESS; ANTI-IL-5 MONOCLONAL-ANTIBODY; COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; SOLUBLE IL-4 RECEPTOR; IN-VIVO TREATMENT; INDUCED EOSINOPHIL INFILTRATION; ALLERGIC MUCOSAL SENSITIZATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
202
Recensione:
Indirizzi per estratti:
Indirizzo: Jordana, M McMaster Univ, Ctr Gene Therapeut, Dept Pathol & Mol Med, Div Resp Dis & Allergy,Hlth Sci Ctr, 1200 Main St W,Room 4H21, Hamilton, ON L8N 3Z5, Canada McMaster Univ 1200 Main St W,Room 4H21 Hamilton ON Canada L8N 3Z5
Citazione:
D. Alvarez et al., "Cytokine therapeutics for asthma: An appraisal of current evidence and future prospects", CUR PHARM D, 7(11), 2001, pp. 1059-1081

Abstract

Although current pharmacopoeia is effective in alleviating asthma symptomatology, it is equally unable to modify the fundamental immunological basis of the allergic diathesis. The explosion in knowledge of the immunobiology of cytokines that has occurred in the last decade has remarkably clarified our understanding of the pathogenesis of allergic asthma, and has unleasheda plethora of compelling opportunities. In the first part of this review, we will summarize current knowledge on the pathogenesis of allergic asthma,with particular emphasis on relevant cytokine networks. This will positionus to appraise critically initiatives in the search to modulate cytokine targets that are key to the expression of the allergic asthma phenotype. We will review the use of recombinant cytokines, soluble cytokine receptors, cytokine receptor antagonists and cytokine inhibitors, in pre-clinical and clinical development. Finally, we will assess the applicability of transgene-based modalities, including anti-sense oligonucleotide technology and genetherapy, as novel therapeutic strategies in the treatment of allergic asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:19:16