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Titolo:
Role of cytokines in allograft rejection
Autore:
Gorczynski, RM;
Indirizzi:
Toronto Hosp, Transplant Res Div, Univ Hlth Network, Toronto, ON M5G 2C4, Canada Toronto Hosp Toronto ON Canada M5G 2C4 twork, Toronto, ON M5G 2C4, Canada
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 11, volume: 7, anno: 2001,
pagine: 1039 - 1057
SICI:
1381-6128(200107)7:11<1039:ROCIAR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; MESSENGER-RNA EXPRESSION; TUMOR-NECROSIS-FACTOR; EXPERIMENTAL-ALLERGIC-ENCEPHALOMYELITIS; BONE-MARROW TRANSPLANTATION; PORTAL VENOUS IMMUNIZATION; ANTIGEN-PRESENTING CELLS; TH2 IMMUNE-RESPONSE; ACTIVATED B-CELLS; CD8(+) T-CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
164
Recensione:
Indirizzi per estratti:
Indirizzo: Gorczynski, RM Toronto Hosp, Transplant Res Div, Univ Hlth Network, CCRW 2-855,200 Elizabeth St, Toronto, ON M5G 2C4, Canada Toronto Hosp CCRW 2-855,200 Elizabeth St Toronto ON Canada M5G 2C4
Citazione:
R.M. Gorczynski, "Role of cytokines in allograft rejection", CUR PHARM D, 7(11), 2001, pp. 1039-1057

Abstract

This review examines the evidence, both from experimental models and numerous clinical settings, that has suggested that suppression of acute allograft rejection correlates with a relative decrease in type-1 cytokine production and an increase in type-2 cytokine production. This correlation has spurred studies on cytokine gene polymorphisms, to assess evidence that certain cytokine-producing genotypes are associated with increased incidence of transplant rejection, and also an interest in the value of monitoring cytokine profiles post-transplantation in long-term follow-up of transplant patients. An appraisal is given of the potential for cytokine gene therapy in transplantation, using both dendritic cells (DC) and graft tissue itself as target cells. Along the same lines, gene-targeting of DCs to increase or decrease expression of molecules (CD40/CD80/CD86/CD200) believed to control the polarization of T cell development land cytokine production) is discussed. The review concludes with consideration of the possibility that one future goal of the pharmaceutical industry will be to develop novel immunosuppressants with selective inhibitory action on the production of distinct cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 02:08:38