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Titolo:
Signal transduction pathways in sarcoma as targets for therapeutic intervention
Autore:
Tuveson, DA; Fletcher, JA;
Indirizzi:
Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 pt Pathol, Boston, MA 02115 USA MIT, Ctr Canc, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Ctr Canc, Cambridge, MA 02139 USA MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA MIT Cambridge MA USA02139 oward Hughes Med Inst, Cambridge, MA 02139 USA Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Med, Boston, MA 02115 USA Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA Dana Farber Canc Inst Boston MA USA 02115 ult Oncol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA
Titolo Testata:
CURRENT OPINION IN ONCOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 249 - 255
SICI:
1040-8746(200107)13:4<249:STPISA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL STROMAL TUMORS; NEUROFIBROMATOSIS TYPE-1 GENE; TYROSINE KINASE INHIBITOR; ROUND-CELL TUMOR; INFLAMMATORY MYOFIBROBLASTIC TUMOR; C-KIT; CONGENITAL FIBROSARCOMA; MESOBLASTIC NEPHROMA; INTERSTITIAL-CELLS; IN-VITRO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Fletcher, JA Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA 02115 5 USA
Citazione:
D.A. Tuveson e J.A. Fletcher, "Signal transduction pathways in sarcoma as targets for therapeutic intervention", CURR OPIN O, 13(4), 2001, pp. 249-255

Abstract

Investigations into the molecular alterations in sarcomas have made substantial progress during the past decade. Classical linkage analysis and the direct sequencing of chromosomal translocation fusions have identified candidate genes in many different sarcomas, A large group of these genes participate in signal transduction pathways and represent potential sites of disease intervention with targeted therapies. This review will discuss five types of sarcoma that display aberrant tyrosine kinase pathway signaling: gastrointestinal stromal tumor, inflammatory myofibroblastic tumor, congenital fibrosarcoma and mesoblastic nephroma, dermatofibrosarcoma protuberans, and desmoplastic small round cell tumor; one sarcoma predisposition syndrome with specific dysregulation of the ras pathway-neurofibromatosis-will also bediscussed. (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:29:48