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Titolo:
Immunoisolation cell therapy for CNS diseases
Autore:
Emerich, DF; Winn, SR;
Indirizzi:
Alkermes Inc, Dept Neurosci, Cambridge, MA 02139 USA Alkermes Inc Cambridge MA USA 02139 ept Neurosci, Cambridge, MA 02139 USA Oregon Hlth Sci Univ, Dept Surg, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 t Surg, Portland, OR 97201 USA
Titolo Testata:
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
fascicolo: 3, volume: 18, anno: 2001,
pagine: 265 - 298
SICI:
0743-4863(2001)18:3<265:ICTFCD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; CILIARY NEUROTROPHIC FACTOR; ADRENAL CHROMAFFIN CELLS; BASAL FOREBRAIN NEURONS; PROGRESSIVE MOTOR NEURONOPATHY; BIOLOGICALLY DELIVERED NGF; ENCAPSULATED PC12 CELLS; GROWTH-FACTOR; HUNTINGTONS-DISEASE;
Keywords:
polymer; encapsulation; immunoisolation; cell therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Emerich, DF Alkermes Inc, Dept Neurosci, 64 Sidney St, Cambridge, MA 02139USA Alkermes Inc 64 Sidney St Cambridge MA USA 02139 MA 02139 USA
Citazione:
D.F. Emerich e S.R. Winn, "Immunoisolation cell therapy for CNS diseases", CR R THER, 18(3), 2001, pp. 265-298

Abstract

Delivery of potentially therapeutic drugs to the brain is hindered by the blood-brain barrier (BBB), which restricts the diffusion of drugs from the vasculature to the brain parenchyma. One means of overcoming the BBB is with cellular implants that produce and deliver therapeutic molecules directlyinto the CNS region of interest. In this paper we describe the current status of one iteration of cell-based therapy that uses xenogeneic cells encased within a selectively permeable polymeric membrane; this is known as immunoisolation. For the purposes of this review, cell immunoisolation for treating CNS diseases is presented in terms of device configurations, membrane manufacturing, characterization in relevant preclinical model systems, and the current status of clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:45:28