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Titolo:
New rat model for attention deficit hyperactive disorder (ADHD)
Autore:
Kamimura, E; Ueno, Y; Tanaka, S; Sawa, H; Yoshioka, M; Ueno, K; Inoue, T; Li, XB; Koyama, T; Ishikawa, R; Nagashima, K;
Indirizzi:
Hokkaido Univ, Sch Med, Lab Mol & Cellular Pathol, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ, Sch Med, Ctr Expt Plants & Anim, Sapporo, Hokkaido 0608638,Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 poro, Hokkaido 0608638,Japan Hokkaido Univ, Sch Med, Dept Pharmacol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ, Sch Med, Dept Psychiat, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
COMPARATIVE MEDICINE
fascicolo: 3, volume: 51, anno: 2001,
pagine: 245 - 251
SICI:
1532-0820(200106)51:3<245:NRMFAD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION BEHAVIOR; TRANSIENT CEREBRAL-ISCHEMIA; ANIMAL-MODEL; ANTERIOR FOREBRAIN; D-AMPHETAMINE; MOUSE MUTANT; MICE; MEMORY; HYPERKINESIA; ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Nagashima, K Hokkaido Univ, Sch Med, Lab Mol & Cellular Pathol, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Kita 15,Nishi 7 Sapporo Hokkaido Japan 0608638
Citazione:
E. Kamimura et al., "New rat model for attention deficit hyperactive disorder (ADHD)", COMPAR MED, 51(3), 2001, pp. 245-251

Abstract

Purpose: In a strain of the Long-Evans Cinnamon (LEC) rats, we found spontaneously hyperactive animals designated as "wiggling," and established a congenic wiggling (Wig) rat by transferring the gene from the LEC to the Wistar King-Aptekman/Hokkaido (WKAH) strain. We evaluated the feasibility of the Wig rat for an animal model of human attention deficit hyperactive disorder (ADHD). Methods: Mode of inheritance was examined by use of linkage analyses. Motor activity, behavior, and working memory were assessed by use of electric digital counters, open field test, and Y-maze and water-maze tests. Results: The abnormal behavior, including hyperactivity, was transmitted in autosomal recessive mode. Diurnal and nocturnal motor activity of 12- to 14-week-old Wig rats was markedly higher than that of controls, and this hyperactivity was more prominent during nighttime than daytime. Ambulation inthe open-field test was significantly increased in Wig rats, but rearing was decreased in Wig rats, compared with controls. Results of the Y-maze tests indicated that spontaneous alternation behavior was significantly impaired in Wig rats, although there was no difference in the total arm entries. The water-maze test could not be performed because, when exposed to water, Wig rats panicked and almost drowned. Conclusions: Wig rats are hyperactive and have impaired working memory andimpulsive behavior, as assessed by the motor activity and open-field testsand the Y-maze test, and these abnormalities are transmitted by a single gene with Mendelian pattern. Wig rats represent an excellent animal model ofhuman ADHD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:47:22