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Titolo:
Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with hepatic fatty acid synthesis and metabolism of male chickens (Gallus domesticus)
Autore:
Stanton, B; Watkins, S; German, JB; Lasley, B;
Indirizzi:
Univ Calif Davis, ITEH, Davis, CA 95616 USA Univ Calif Davis Davis CA USA95616 alif Davis, ITEH, Davis, CA 95616 USA FAME Analyt Inc, W Sacramento, CA USA FAME Analyt Inc W Sacramento CA USA AME Analyt Inc, W Sacramento, CA USA Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 od Sci & Technol, Davis, CA 95616 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 2, volume: 129, anno: 2001,
pagine: 137 - 150
SICI:
1532-0456(200106)129:2<137:IOEA2(>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER HEMORRHAGIC SYNDROME; ARYL-HYDROCARBON RECEPTOR; GENE-EXPRESSION; GUINEA-PIG; IN-VIVO; TRANSCRIPTIONAL ACTIVATION; LIPOPROTEIN-LIPASE; WASTING SYNDROME; DIOXIN TOXICITY; ADIPOSE-TISSUE;
Keywords:
chicken; estrogen; fatty acid; liver; phospholipid; 2.3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); triacylglyceride; wasting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Stanton, B Univ Calif Davis, ITEH, 1 Shields Ave, Davis, CA 95616 USA UnivCalif Davis 1 Shields Ave Davis CA USA 95616 CA 95616 USA
Citazione:
B. Stanton et al., "Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with hepatic fatty acid synthesis and metabolism of male chickens (Gallus domesticus)", COMP BIOC C, 129(2), 2001, pp. 137-150

Abstract

This study tested the hypothesis that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) antagonizes estrogen-induced hepatic lipid synthesis and metabolism in birds. Twenty immature male chickens (Gallus domesticus) were divided evenly into four groups: (1) vehicle control; (2) estrogen alone (1.0 mg/kg estradiol cypionate injected on three consecutive days); (3) TCDD alone (50 mug/kg injected on the fourth clay); and (4) a combination of the estrogen and TCDD treatments. On day 14, liver samples were collected fear quantitative fatty acid analysis by capillary gas chromatography. Birds treated withestrogen alone had increased total triacylglyceride concentrations with specific increases in the Delta9 desaturase products 16:1n7, 18:1n7, 18:1n9, and 20:1n9. In addition, estrogen treatment specifically increased 22:6n3 concentrations in both triacylglycerides and phospholipids. However, these increases in Delta9 desaturase products or 22:6n3 did not occur for birds treated with estrogen in combination with TCDD. TCDD and estrogen plus TCDD treatments increased phospholipid concentrations of the diet-derived polyunsaturated fatty acids 18:2n6, 18:3n6, 20:3n6, 18:3n3, and 20:5n3, although only the estrogen plus TCDD group had significantly increased total phospholipids. In cholesterol esters, all three treatments decreased concentrationsof total fatty acids, saturated fatty acids, and Delta9 desaturase products compared to the control group. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:51:21